Performance of a 3-Bladed Propeller Pump to Provide Cavopulmonary Assist in the Failing Fontan Circulation

Amy L. Throckmorton, Kimberly K. Ballman, Cynthia D. Myers, Steven H. Frankel, John Brown, Mark Rodefeld

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose: We hypothesized that a propeller pump design would function optimally to provide cavopulmonary assist in a univentricular Fontan circulation. Description: The hydraulic and hemolysis performance of a rigid three-bladed propeller prototype (similar to a folding propeller design) was characterized. Pressure and flow measurements were taken for flow rates of 0.5 to 3 liters per minute (LPM) for 5,000 to 7,000 revolutions per minute (RPM) using a blood analog fluid. Hemolysis testing was performed using fresh bovine blood for 2 LPM at 6,000 RPM for a 6-hour duration. Evaluation: The prototype performed well over the design operating range by producing a pressure rise of 5 to 50 mm Hg. Plasma free hemoglobin concentration remained less than 15 mg/dL. The normalized index of hemolysis peaked during the first hour, and then remained less than 10 mg/dL thereafter. Conclusions: A propeller pump has the pressure-flow characteristics and minimal risk of hemolysis and venous pathway obstruction which make it ideal for temporary cavopulmonary assist. This type of device has the potential to provide a new therapeutic option for patients with failing univentricular Fontan physiology as a bridge-to-recovery or transplantation.

Original languageEnglish
Pages (from-to)1343-1347
Number of pages5
JournalAnnals of Thoracic Surgery
Volume86
Issue number4
DOIs
StatePublished - Oct 2008

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Hemolysis
Pressure
Hemoglobins
Transplantation
Equipment and Supplies
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Performance of a 3-Bladed Propeller Pump to Provide Cavopulmonary Assist in the Failing Fontan Circulation. / Throckmorton, Amy L.; Ballman, Kimberly K.; Myers, Cynthia D.; Frankel, Steven H.; Brown, John; Rodefeld, Mark.

In: Annals of Thoracic Surgery, Vol. 86, No. 4, 10.2008, p. 1343-1347.

Research output: Contribution to journalArticle

Throckmorton, Amy L. ; Ballman, Kimberly K. ; Myers, Cynthia D. ; Frankel, Steven H. ; Brown, John ; Rodefeld, Mark. / Performance of a 3-Bladed Propeller Pump to Provide Cavopulmonary Assist in the Failing Fontan Circulation. In: Annals of Thoracic Surgery. 2008 ; Vol. 86, No. 4. pp. 1343-1347.
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