Performance of a 62Zn/62Cu microgenerator in kit-based synthesis and delivery of [62Cu]Cu-ETS for PET perfusion imaging

Yen Ng, Jeffrey L. Lacy, James Fletcher, Mark Green

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The performance of a commercially produced 62Zn/62Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [62Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84±0.23GBq 62Zn at 9:00AM on the day of clinical use, a total of 45 patient doses of [62Cu]Cu-ETS (672±172MBq) were delivered without difficulty. 62Cu elution yields were high (approximately 90%), accompanied by extremely low 62Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The 62Zn/62Cu microgenerator was a dependable source of short-lived positron-emitting 62Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for "on-demand" delivery of [62Cu]Cu-ETS for PET perfusion imaging.

Original languageEnglish
Pages (from-to)38-43
Number of pages6
JournalApplied Radiation and Isotopes
Volume91
DOIs
StatePublished - 2014

Fingerprint

kits
elution
Perfusion Imaging
delivery
Radiopharmaceuticals
synthesis
positrons
generators
injection
copper
dosage
preparation
Electrons
Injections
ethylglyoxal bis(thiosemicarbazonato)copper(II)

Keywords

  • PET radiopharmaceuticals
  • Tumor perfusion

ASJC Scopus subject areas

  • Radiation
  • Medicine(all)

Cite this

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title = "Performance of a 62Zn/62Cu microgenerator in kit-based synthesis and delivery of [62Cu]Cu-ETS for PET perfusion imaging",
abstract = "The performance of a commercially produced 62Zn/62Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [62Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84±0.23GBq 62Zn at 9:00AM on the day of clinical use, a total of 45 patient doses of [62Cu]Cu-ETS (672±172MBq) were delivered without difficulty. 62Cu elution yields were high (approximately 90{\%}), accompanied by extremely low 62Zn breakthrough (<0.001{\%}). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The 62Zn/62Cu microgenerator was a dependable source of short-lived positron-emitting 62Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for {"}on-demand{"} delivery of [62Cu]Cu-ETS for PET perfusion imaging.",
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AU - Green, Mark

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N2 - The performance of a commercially produced 62Zn/62Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [62Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84±0.23GBq 62Zn at 9:00AM on the day of clinical use, a total of 45 patient doses of [62Cu]Cu-ETS (672±172MBq) were delivered without difficulty. 62Cu elution yields were high (approximately 90%), accompanied by extremely low 62Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The 62Zn/62Cu microgenerator was a dependable source of short-lived positron-emitting 62Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for "on-demand" delivery of [62Cu]Cu-ETS for PET perfusion imaging.

AB - The performance of a commercially produced 62Zn/62Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [62Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84±0.23GBq 62Zn at 9:00AM on the day of clinical use, a total of 45 patient doses of [62Cu]Cu-ETS (672±172MBq) were delivered without difficulty. 62Cu elution yields were high (approximately 90%), accompanied by extremely low 62Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The 62Zn/62Cu microgenerator was a dependable source of short-lived positron-emitting 62Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for "on-demand" delivery of [62Cu]Cu-ETS for PET perfusion imaging.

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