Performance of a 62Zn/62Cu microgenerator in kit-based synthesis and delivery of [62Cu]Cu-ETS for PET perfusion imaging

Yen Ng, Jeffrey L. Lacy, James W. Fletcher, Mark A. Green

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The performance of a commercially produced 62Zn/62Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [62Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84±0.23GBq 62Zn at 9:00AM on the day of clinical use, a total of 45 patient doses of [62Cu]Cu-ETS (672±172MBq) were delivered without difficulty. 62Cu elution yields were high (approximately 90%), accompanied by extremely low 62Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The 62Zn/62Cu microgenerator was a dependable source of short-lived positron-emitting 62Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for "on-demand" delivery of [62Cu]Cu-ETS for PET perfusion imaging.

Original languageEnglish (US)
Pages (from-to)38-43
Number of pages6
JournalApplied Radiation and Isotopes
Volume91
DOIs
StatePublished - Sep 2014

Keywords

  • PET radiopharmaceuticals
  • Tumor perfusion

ASJC Scopus subject areas

  • Radiation
  • Medicine(all)

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