Performance of candidate urinary biomarkers for pancreatic cancer - Correlation with pancreatic cyst malignant progression?

Michele T. Yip-Schneider, Mazhar Soufi, Rosalie A. Carr, Katelyn F. Flick, Huangbing Wu, Cameron L. Colgate, C. Max Schmidt

Research output: Contribution to journalArticle

Abstract

Background: Intraductal papillary mucinous neoplasms (IPMN) are precursors of pancreatic cancer. Potential biomarkers of IPMN progression have not been identified in urine. A few urinary biomarkers were reported to be predictive of pancreatic ductal adenocarcinoma (PDAC). Here, we seek to assess their ability to detect high-risk IPMN. Methods: Urine was collected from patients undergoing pancreatic resection and healthy controls. TIMP-1(Tissue Inhibitor of Metalloproteinase-1), LYVE-1(Lymphatic Vessel Endothelial Receptor 1), and PGEM(Prostaglandin E Metabolite) levels were determined by ELISA and analyzed by Kruskal-Wallis. Results: Median urinary TIMP-1 levels were significantly lower in healthy controls (n = 9; 0.32 ng/mg creatinine) compared to PDAC (n = 13; 1.95) but not significantly different between low/moderate-grade (n = 20; 0.71) and high-grade/invasive IPMN (n = 20; 1.12). No significant difference in urinary LYVE-1 was detected between IPMN low/moderate (n = 16; 0.37 ng/mg creatinine) and high/invasive grades (n = 21; 0.09). Urinary PGEM levels were not significantly different between groups. Conclusions: Urinary TIMP-1, LYVE-1, and PGEM do not correlate with malignant potential of pancreatic cysts.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalAmerican Journal of Surgery
Volume219
Issue number3
DOIs
StatePublished - Mar 2020

Keywords

  • Biomarker
  • Dysplasia
  • Intraductal papillary mucinous neoplasm
  • Pancreatic cancer
  • Pancreatic cyst
  • Urine

ASJC Scopus subject areas

  • Surgery

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