Performance of colour Doppler imaging discriminating normal tension glaucoma from healthy eyes

N. Plange, M. Kaup, A. Weber, Alon Harris, K. O. Arend, A. Remky

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: Previous studies have shown decreased retrobulbar blood flow in normal tension glaucoma (NTG) compared to healthy controls. This study evaluates the ability of colour Doppler imaging (CDI) to identify patients with NTG. Methods: Sixty-two patients with untreated NTG (mean age 57±14 years) and 40 age-matched controls (mean age 58±9 years) were included in a prospective cross-sectional institutional study. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive indices (RI=(PSV-EDV)/PSV) of the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs) were measured by means of CDI. Using receiver operating characteristic (ROC) curves, sensitivity was determined at 90% specificity. Results: Patients with NTG showed significantly decreased PSV (P<0.0001) and EDV (P<0.0001) of the CRA, significantly decreased EDV of the nasal (P=0.004) and temporal (P=0.002) PCA, and significantly increased RI of the temporal (P=0.003) PCAs compared to healthy controls. Sensitivity values at 90% specificity were calculated: PSV of the CRA, 30.6%; EDV of the CRA, 48.4%; EDV of the nasal PCA, 43.9%; EDV of the temporal PCA, 45.9%; and RI of the temporal PCA, 39.3%. Conclusions: The power to identify NTG using CDI reaches 48% sensitivity at 90% specificity. Further longitudinal studies are needed to determine the prognostic value of CDI in glaucoma.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalEye (Basingstoke)
Volume23
Issue number1
DOIs
StatePublished - Jan 2009

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Ciliary Arteries
Low Tension Glaucoma
Retinal Artery
Color
Nose
Ophthalmic Artery
ROC Curve
Glaucoma
Longitudinal Studies
Cross-Sectional Studies

Keywords

  • Colour Doppler imaging
  • Normal tension glaucoma
  • Ocular blood flow
  • Receiver operating characteristics
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Performance of colour Doppler imaging discriminating normal tension glaucoma from healthy eyes. / Plange, N.; Kaup, M.; Weber, A.; Harris, Alon; Arend, K. O.; Remky, A.

In: Eye (Basingstoke), Vol. 23, No. 1, 01.2009, p. 164-170.

Research output: Contribution to journalArticle

Plange, N. ; Kaup, M. ; Weber, A. ; Harris, Alon ; Arend, K. O. ; Remky, A. / Performance of colour Doppler imaging discriminating normal tension glaucoma from healthy eyes. In: Eye (Basingstoke). 2009 ; Vol. 23, No. 1. pp. 164-170.
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abstract = "Purpose: Previous studies have shown decreased retrobulbar blood flow in normal tension glaucoma (NTG) compared to healthy controls. This study evaluates the ability of colour Doppler imaging (CDI) to identify patients with NTG. Methods: Sixty-two patients with untreated NTG (mean age 57±14 years) and 40 age-matched controls (mean age 58±9 years) were included in a prospective cross-sectional institutional study. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive indices (RI=(PSV-EDV)/PSV) of the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs) were measured by means of CDI. Using receiver operating characteristic (ROC) curves, sensitivity was determined at 90{\%} specificity. Results: Patients with NTG showed significantly decreased PSV (P<0.0001) and EDV (P<0.0001) of the CRA, significantly decreased EDV of the nasal (P=0.004) and temporal (P=0.002) PCA, and significantly increased RI of the temporal (P=0.003) PCAs compared to healthy controls. Sensitivity values at 90{\%} specificity were calculated: PSV of the CRA, 30.6{\%}; EDV of the CRA, 48.4{\%}; EDV of the nasal PCA, 43.9{\%}; EDV of the temporal PCA, 45.9{\%}; and RI of the temporal PCA, 39.3{\%}. Conclusions: The power to identify NTG using CDI reaches 48{\%} sensitivity at 90{\%} specificity. Further longitudinal studies are needed to determine the prognostic value of CDI in glaucoma.",
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N2 - Purpose: Previous studies have shown decreased retrobulbar blood flow in normal tension glaucoma (NTG) compared to healthy controls. This study evaluates the ability of colour Doppler imaging (CDI) to identify patients with NTG. Methods: Sixty-two patients with untreated NTG (mean age 57±14 years) and 40 age-matched controls (mean age 58±9 years) were included in a prospective cross-sectional institutional study. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive indices (RI=(PSV-EDV)/PSV) of the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs) were measured by means of CDI. Using receiver operating characteristic (ROC) curves, sensitivity was determined at 90% specificity. Results: Patients with NTG showed significantly decreased PSV (P<0.0001) and EDV (P<0.0001) of the CRA, significantly decreased EDV of the nasal (P=0.004) and temporal (P=0.002) PCA, and significantly increased RI of the temporal (P=0.003) PCAs compared to healthy controls. Sensitivity values at 90% specificity were calculated: PSV of the CRA, 30.6%; EDV of the CRA, 48.4%; EDV of the nasal PCA, 43.9%; EDV of the temporal PCA, 45.9%; and RI of the temporal PCA, 39.3%. Conclusions: The power to identify NTG using CDI reaches 48% sensitivity at 90% specificity. Further longitudinal studies are needed to determine the prognostic value of CDI in glaucoma.

AB - Purpose: Previous studies have shown decreased retrobulbar blood flow in normal tension glaucoma (NTG) compared to healthy controls. This study evaluates the ability of colour Doppler imaging (CDI) to identify patients with NTG. Methods: Sixty-two patients with untreated NTG (mean age 57±14 years) and 40 age-matched controls (mean age 58±9 years) were included in a prospective cross-sectional institutional study. Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive indices (RI=(PSV-EDV)/PSV) of the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs) were measured by means of CDI. Using receiver operating characteristic (ROC) curves, sensitivity was determined at 90% specificity. Results: Patients with NTG showed significantly decreased PSV (P<0.0001) and EDV (P<0.0001) of the CRA, significantly decreased EDV of the nasal (P=0.004) and temporal (P=0.002) PCA, and significantly increased RI of the temporal (P=0.003) PCAs compared to healthy controls. Sensitivity values at 90% specificity were calculated: PSV of the CRA, 30.6%; EDV of the CRA, 48.4%; EDV of the nasal PCA, 43.9%; EDV of the temporal PCA, 45.9%; and RI of the temporal PCA, 39.3%. Conclusions: The power to identify NTG using CDI reaches 48% sensitivity at 90% specificity. Further longitudinal studies are needed to determine the prognostic value of CDI in glaucoma.

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