Performance of point-of-care diagnostics for glucose, lactate, hemoglobin in the management of severe malaria in a resource-constrained hospital in Uganda

Michael Hawkes, Andrea L. Conroy, Robert O. Opoka, Sophie Namasopo, W. Conrad Liles, Chandy C. John, Kevin C. Kain

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Severe malaria is frequently managed without access to laboratory testing. We report on the performance of point-of-care tests used to guide the management of a cohort of 179 children with severe malaria in a resource-limited Ugandan hospital. Correlation coefficients between paired measurements for glucose (i-STAT and One Touch Ultra), lactate (i-STAT and Lactate Scout), and hemoglobin (Hb; laboratory and i-STAT) were 0.86, 0.85, and 0.73, respectively. The OneTouch Ultra glucometer readings deviated systematically from the i-STAT values by +1.7 mmol/L. Lactate Scout values were systematically higher than i-STAT by +0.86 mmol/L. Lactate measurements from either device predicted subsequent mortality. Hb estimation by the i-STAT instrument was unbiased, with upper and lower limits of agreement of -34 and +34 g/L, and it was 91% sensitive and 89% specific for the diagnosis of severe anemia (Hb < 50 g/L). New commercially available bedside diagnostic tools, although imperfect, may expedite clinical decision-making in the management of critically ill children in resource-constrained settings.

Original languageEnglish (US)
Pages (from-to)605-608
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume90
Issue number4
DOIs
StatePublished - Apr 2014
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Performance of point-of-care diagnostics for glucose, lactate, hemoglobin in the management of severe malaria in a resource-constrained hospital in Uganda'. Together they form a unique fingerprint.

  • Cite this