The sphincter of Oddi (SO) is a complex smooth muscle structure surrounding the terminal common bile duct, main pancreatic duct, and common channel, when present (Figure 1). The high-pressure zone generated by the sphincter varies from 4-10 mm in length. The SO regulates the flow of bile and pancreatic exocrine juice and prevents duodenum-to-duct reflux, maintaining a sterile intraductal environment. The SO possesses basal pressure and phasic contractile activities; the former is the predominant mechanism regulating flow of pancreatobiliary secretions. The phasic SO contractions, though aiding in emission of bile and pancreatic juices, primarily function to prevent intraductal infection.
|Original language||English (US)|
|Number of pages||9|
|Journal||Clinical Perspectives in Gastroenterology|
|State||Published - Jan 1 2001|
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