Perfusion heterogeneity in the pulmonary acinus

Nobuhiro Tanabe, Thomas M. Todoran, Gerald M. Zenk, Brenda R. Bunton, Wiltz W. Wagner, Robert Presson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

There is little information on the distribution of acinar perfusion because it is difficult to resolve blood flow within such small regions. We hypothesized that the known heterogeneity of arteriolar blood flow and capillary blood flow would result in heterogeneous acinar perfusion. To test this hypothesis, the passage of fluorescent dye boluses through the subpleural microcirculation of isolated dog lobes was videotaped by using fluorescence microscopy. As the videotapes were replayed, dye-dilution curves were recorded from each of the tributary branches of Y-shaped venules that drained an acinus. From the dye curves, we calculated the mean appearance time of each curve. The difference in mean appearance times between venular tributary branches was small in most cases. In 43% of the observed venular branch pairs, the dye curves were essentially superimposable (the mean appearance-time difference was <5%); and in another 42%, the mean appearance- time difference between curves was 5-10%. From these results, we conclude that acinar perfusion is unexpectedly homogeneous.

Original languageEnglish
Pages (from-to)933-938
Number of pages6
JournalJournal of Applied Physiology
Volume84
Issue number3
StatePublished - Mar 1998

Fingerprint

Perfusion
Lung
Coloring Agents
Videotape Recording
Venules
Information Dissemination
Microcirculation
Fluorescent Dyes
Fluorescence Microscopy
Dogs

Keywords

  • Acinar perfusion
  • Dogs
  • Pulmonary microcirculation

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Tanabe, N., Todoran, T. M., Zenk, G. M., Bunton, B. R., Wagner, W. W., & Presson, R. (1998). Perfusion heterogeneity in the pulmonary acinus. Journal of Applied Physiology, 84(3), 933-938.

Perfusion heterogeneity in the pulmonary acinus. / Tanabe, Nobuhiro; Todoran, Thomas M.; Zenk, Gerald M.; Bunton, Brenda R.; Wagner, Wiltz W.; Presson, Robert.

In: Journal of Applied Physiology, Vol. 84, No. 3, 03.1998, p. 933-938.

Research output: Contribution to journalArticle

Tanabe, N, Todoran, TM, Zenk, GM, Bunton, BR, Wagner, WW & Presson, R 1998, 'Perfusion heterogeneity in the pulmonary acinus', Journal of Applied Physiology, vol. 84, no. 3, pp. 933-938.
Tanabe N, Todoran TM, Zenk GM, Bunton BR, Wagner WW, Presson R. Perfusion heterogeneity in the pulmonary acinus. Journal of Applied Physiology. 1998 Mar;84(3):933-938.
Tanabe, Nobuhiro ; Todoran, Thomas M. ; Zenk, Gerald M. ; Bunton, Brenda R. ; Wagner, Wiltz W. ; Presson, Robert. / Perfusion heterogeneity in the pulmonary acinus. In: Journal of Applied Physiology. 1998 ; Vol. 84, No. 3. pp. 933-938.
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