Pergolide, a potent long-acting dopamine-receptor agonist

Louis Lemberger, Ross Crabtree, J. Thomas Callaghan

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Abstract

After single doses (100 to 400 μg orally), pergolide, a synthetic ergot, reduced basal plasma prolactin levels in normal subjects in a dose-related manner. This effect persisted for more than 24 hr. Multiple doses of pergolide (150 to 250 μg daily for 7 days) resulted in a plasma prolactin decrease of more than 80%. A single dose of pergolide (150 μg orally) suppressed plasma prolactin and abolished the plasma prolactin diurnal rhythm, i.e., suppression of sleep-induced elevation in plasma prolactin during a 40-hr period. Perphenazine (5 mg intramuscularly)-induced plasma prolactin elevation was inhibited by pergolide; the effect was dose dependent. After single or multiple doses, pergolide had no effect on plasma follicle-stimulating hormone, luteinizing hormone, cortisol, growth hormone, and thyroid-stimulating hormone. Pergolide appears to have .specificity at the pituitary, level for the dopamine receptors that mediate prolactin secretion.

Original languageEnglish (US)
Pages (from-to)642-651
Number of pages10
JournalClinical Pharmacology and Therapeutics
Volume27
Issue number5
DOIs
StatePublished - May 1980

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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