Pericentric X inversion in dizygotic twins who differ in X chromosome inactivation and menstrual cycle function

Elisabeth A. Keitges, Catherine G. Palmer, David D. Weaver

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A 21-year-old female dizygotic twin was referred for cytogenetic evaluation because of mild mental retardation. Significant history, clinical, and physical findings included irregular menses, mildly coarse facies, and microcornea. Chromosome analysis revealed a pericentric inversion of the X chromosome, 46,X,inv(X)(p11;q22). Her twin who is phenotypically normal was also found to carry the same inversion. The twins differ significantly in X chromosome inactivation and menstrual cycle function.

Original languageEnglish (US)
Pages (from-to)210-213
Number of pages4
JournalHuman Genetics
Volume62
Issue number3
DOIs
StatePublished - Dec 1 1982

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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