Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets

L. Ye, S. Zhang, H. Ke, Lynda Bonewald, J. Q. Feng

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Dentin Matrix Protein 1 (DMP1) is highly expressed in alveolar bone and cementum, which are important components of the periodontium. Therefore, we hypothesized that Dmp1 is critical for the integrity of the periodontium, and that deletion may lead to increased susceptibility to disease. An early-onset periodontal defect was observed in the Dmp1 null mouse, a mouse model of hypophosphatemic rickets. The alveolar bone is porous, with increased proteoglycan expression. The cementum is also defective, as characterized by irregular, punctate fluorochrome labeling and elevated proteoglycan. The osteocyte and cementocyte lacuno-canalicular system of both alveolar bone and cementum is abnormal, with irregular lacunar walls and fewer canaliculi. As a consequence, there is significant interproximal alveolar bone loss, combined with detachment between the periodontal ligament (PDL) and cementum. We propose that defective alveolar bone and cementum may account for the periodontal breakdown and increased susceptibility to bacterial infection in Dmp1 null mice.

Original languageEnglish (US)
Pages (from-to)624-629
Number of pages6
JournalJournal of Dental Research
Volume87
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

Hypophosphatemic Rickets
Dental Cementum
Bone and Bones
Periodontium
Proteoglycans
Alveolar Bone Loss
Osteocytes
Periodontal Ligament
Disease Susceptibility
Dentin
Fluorescent Dyes
Bacterial Infections
Proteins

Keywords

  • Alveolar bone
  • Cementum
  • DMP1
  • Hypophosphatemic rickets
  • PDL

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets. / Ye, L.; Zhang, S.; Ke, H.; Bonewald, Lynda; Feng, J. Q.

In: Journal of Dental Research, Vol. 87, No. 7, 07.2008, p. 624-629.

Research output: Contribution to journalArticle

Ye, L. ; Zhang, S. ; Ke, H. ; Bonewald, Lynda ; Feng, J. Q. / Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets. In: Journal of Dental Research. 2008 ; Vol. 87, No. 7. pp. 624-629.
@article{0fd751a916834d829dec4a685d52841f,
title = "Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets",
abstract = "Dentin Matrix Protein 1 (DMP1) is highly expressed in alveolar bone and cementum, which are important components of the periodontium. Therefore, we hypothesized that Dmp1 is critical for the integrity of the periodontium, and that deletion may lead to increased susceptibility to disease. An early-onset periodontal defect was observed in the Dmp1 null mouse, a mouse model of hypophosphatemic rickets. The alveolar bone is porous, with increased proteoglycan expression. The cementum is also defective, as characterized by irregular, punctate fluorochrome labeling and elevated proteoglycan. The osteocyte and cementocyte lacuno-canalicular system of both alveolar bone and cementum is abnormal, with irregular lacunar walls and fewer canaliculi. As a consequence, there is significant interproximal alveolar bone loss, combined with detachment between the periodontal ligament (PDL) and cementum. We propose that defective alveolar bone and cementum may account for the periodontal breakdown and increased susceptibility to bacterial infection in Dmp1 null mice.",
keywords = "Alveolar bone, Cementum, DMP1, Hypophosphatemic rickets, PDL",
author = "L. Ye and S. Zhang and H. Ke and Lynda Bonewald and Feng, {J. Q.}",
year = "2008",
month = "7",
doi = "10.1177/154405910808700708",
language = "English (US)",
volume = "87",
pages = "624--629",
journal = "Journal of Dental Research",
issn = "0022-0345",
publisher = "SAGE Publications Inc.",
number = "7",

}

TY - JOUR

T1 - Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets

AU - Ye, L.

AU - Zhang, S.

AU - Ke, H.

AU - Bonewald, Lynda

AU - Feng, J. Q.

PY - 2008/7

Y1 - 2008/7

N2 - Dentin Matrix Protein 1 (DMP1) is highly expressed in alveolar bone and cementum, which are important components of the periodontium. Therefore, we hypothesized that Dmp1 is critical for the integrity of the periodontium, and that deletion may lead to increased susceptibility to disease. An early-onset periodontal defect was observed in the Dmp1 null mouse, a mouse model of hypophosphatemic rickets. The alveolar bone is porous, with increased proteoglycan expression. The cementum is also defective, as characterized by irregular, punctate fluorochrome labeling and elevated proteoglycan. The osteocyte and cementocyte lacuno-canalicular system of both alveolar bone and cementum is abnormal, with irregular lacunar walls and fewer canaliculi. As a consequence, there is significant interproximal alveolar bone loss, combined with detachment between the periodontal ligament (PDL) and cementum. We propose that defective alveolar bone and cementum may account for the periodontal breakdown and increased susceptibility to bacterial infection in Dmp1 null mice.

AB - Dentin Matrix Protein 1 (DMP1) is highly expressed in alveolar bone and cementum, which are important components of the periodontium. Therefore, we hypothesized that Dmp1 is critical for the integrity of the periodontium, and that deletion may lead to increased susceptibility to disease. An early-onset periodontal defect was observed in the Dmp1 null mouse, a mouse model of hypophosphatemic rickets. The alveolar bone is porous, with increased proteoglycan expression. The cementum is also defective, as characterized by irregular, punctate fluorochrome labeling and elevated proteoglycan. The osteocyte and cementocyte lacuno-canalicular system of both alveolar bone and cementum is abnormal, with irregular lacunar walls and fewer canaliculi. As a consequence, there is significant interproximal alveolar bone loss, combined with detachment between the periodontal ligament (PDL) and cementum. We propose that defective alveolar bone and cementum may account for the periodontal breakdown and increased susceptibility to bacterial infection in Dmp1 null mice.

KW - Alveolar bone

KW - Cementum

KW - DMP1

KW - Hypophosphatemic rickets

KW - PDL

UR - http://www.scopus.com/inward/record.url?scp=47649104793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47649104793&partnerID=8YFLogxK

U2 - 10.1177/154405910808700708

DO - 10.1177/154405910808700708

M3 - Article

VL - 87

SP - 624

EP - 629

JO - Journal of Dental Research

JF - Journal of Dental Research

SN - 0022-0345

IS - 7

ER -