Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin

Oriane Duchamp De Lageneste, Anaïs Julien, Rana Abou-Khalil, Giulia Frangi, Caroline Carvalho, Nicolas Cagnard, Corinne Cordier, Simon Conway, Céline Colnot

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain poorly characterized. Here, we show that periosteum contains SSCs with high bone regenerative potential compared to bone marrow stromal cells/skeletal stem cells (BMSCs) in mice. Although periosteal cells (PCs) and BMSCs are derived from a common embryonic mesenchymal lineage, postnatally PCs exhibit greater clonogenicity, growth and differentiation capacity than BMSCs. During bone repair, PCs can efficiently contribute to cartilage and bone, and integrate long-term after transplantation. Molecular profiling uncovers genes encoding Periostin and other extracellular matrix molecules associated with the enhanced response to injury of PCs. Periostin gene deletion impairs PC functions and fracture consolidation. Periostin-deficient periosteum cannot reconstitute a pool of PCs after injury demonstrating the presence of SSCs within periosteum and the requirement of Periostin in maintaining this pool. Overall our results highlight the importance of analyzing periosteum and PCs to understand bone phenotypes.

Original languageEnglish (US)
Article number773
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

Periosteum
stem cells
Stem cells
bones
Bone
Stem Cells
Bone and Bones
cells
bone marrow
Mesenchymal Stromal Cells
genes
transplantation
deletion
cartilage
phenotype
Bone Regeneration
consolidation
Gene Deletion
Wounds and Injuries
Gene encoding

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Duchamp De Lageneste, O., Julien, A., Abou-Khalil, R., Frangi, G., Carvalho, C., Cagnard, N., ... Colnot, C. (2018). Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nature Communications, 9(1), [773]. https://doi.org/10.1038/s41467-018-03124-z

Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. / Duchamp De Lageneste, Oriane; Julien, Anaïs; Abou-Khalil, Rana; Frangi, Giulia; Carvalho, Caroline; Cagnard, Nicolas; Cordier, Corinne; Conway, Simon; Colnot, Céline.

In: Nature Communications, Vol. 9, No. 1, 773, 01.12.2018.

Research output: Contribution to journalArticle

Duchamp De Lageneste, O, Julien, A, Abou-Khalil, R, Frangi, G, Carvalho, C, Cagnard, N, Cordier, C, Conway, S & Colnot, C 2018, 'Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin', Nature Communications, vol. 9, no. 1, 773. https://doi.org/10.1038/s41467-018-03124-z
Duchamp De Lageneste O, Julien A, Abou-Khalil R, Frangi G, Carvalho C, Cagnard N et al. Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nature Communications. 2018 Dec 1;9(1). 773. https://doi.org/10.1038/s41467-018-03124-z
Duchamp De Lageneste, Oriane ; Julien, Anaïs ; Abou-Khalil, Rana ; Frangi, Giulia ; Carvalho, Caroline ; Cagnard, Nicolas ; Cordier, Corinne ; Conway, Simon ; Colnot, Céline. / Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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