Periostin as a heterofunctional regulator of cardiac development and disease

Simon Conway, Jeffery D. Molkentin

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Periostin (Postn) is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the heart, Postn is expressed in the developing valves, cardiac fibroblasts and in regions of the outflow track. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Here we will review the functional consequences associated with Postn induction in both the developing and adult heart. The majority of data collected to date suggest a common function for Postn in both development and disease as a potent inducible regulator of cellular reorganization and extracellular matrix homeostasis, although some alternate and controversial functions have also been ascribed to Postn, the validity of which will be discussed here.

Original languageEnglish
Pages (from-to)548-555
Number of pages8
JournalCurrent Genomics
Volume9
Issue number8
DOIs
StatePublished - 2008

Fingerprint

Heart Diseases
Epithelial-Mesenchymal Transition
Extracellular Matrix Proteins
Heart Valves
Cardiomyopathies
Embryonic Development
Extracellular Matrix
Homeostasis
Collagen
Fibroblasts
Myocardial Infarction
Pressure
Wounds and Injuries
Growth
Population

Keywords

  • Cardiac
  • Development
  • Hypertrophy
  • Periostin
  • Remodeling
  • Signaling

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Periostin as a heterofunctional regulator of cardiac development and disease. / Conway, Simon; Molkentin, Jeffery D.

In: Current Genomics, Vol. 9, No. 8, 2008, p. 548-555.

Research output: Contribution to journalArticle

@article{5bb73915f9514a97ad1c47303c290f33,
title = "Periostin as a heterofunctional regulator of cardiac development and disease",
abstract = "Periostin (Postn) is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the heart, Postn is expressed in the developing valves, cardiac fibroblasts and in regions of the outflow track. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Here we will review the functional consequences associated with Postn induction in both the developing and adult heart. The majority of data collected to date suggest a common function for Postn in both development and disease as a potent inducible regulator of cellular reorganization and extracellular matrix homeostasis, although some alternate and controversial functions have also been ascribed to Postn, the validity of which will be discussed here.",
keywords = "Cardiac, Development, Hypertrophy, Periostin, Remodeling, Signaling",
author = "Simon Conway and Molkentin, {Jeffery D.}",
year = "2008",
doi = "10.2174/138920208786847917",
language = "English",
volume = "9",
pages = "548--555",
journal = "Current Genomics",
issn = "1389-2029",
publisher = "Bentham Science Publishers B.V.",
number = "8",

}

TY - JOUR

T1 - Periostin as a heterofunctional regulator of cardiac development and disease

AU - Conway, Simon

AU - Molkentin, Jeffery D.

PY - 2008

Y1 - 2008

N2 - Periostin (Postn) is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the heart, Postn is expressed in the developing valves, cardiac fibroblasts and in regions of the outflow track. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Here we will review the functional consequences associated with Postn induction in both the developing and adult heart. The majority of data collected to date suggest a common function for Postn in both development and disease as a potent inducible regulator of cellular reorganization and extracellular matrix homeostasis, although some alternate and controversial functions have also been ascribed to Postn, the validity of which will be discussed here.

AB - Periostin (Postn) is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the heart, Postn is expressed in the developing valves, cardiac fibroblasts and in regions of the outflow track. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Here we will review the functional consequences associated with Postn induction in both the developing and adult heart. The majority of data collected to date suggest a common function for Postn in both development and disease as a potent inducible regulator of cellular reorganization and extracellular matrix homeostasis, although some alternate and controversial functions have also been ascribed to Postn, the validity of which will be discussed here.

KW - Cardiac

KW - Development

KW - Hypertrophy

KW - Periostin

KW - Remodeling

KW - Signaling

UR - http://www.scopus.com/inward/record.url?scp=65949102766&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65949102766&partnerID=8YFLogxK

U2 - 10.2174/138920208786847917

DO - 10.2174/138920208786847917

M3 - Article

VL - 9

SP - 548

EP - 555

JO - Current Genomics

JF - Current Genomics

SN - 1389-2029

IS - 8

ER -