Peripapillary retinal blood flow in normal tension glaucoma

Hak Sung Chung, Alon Harris, Larry Kagemann, Bruce Martin

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Aims - To determine if normal tension glaucoma (NTG) patients differ from age matched controls in blood flow to the peripapillary retina, as measured with confocal scanning laser Doppler flowmetry (cSLDF; 'Heidelberg retinal flowmetry'). Methods - 12 NTG patients and 12 age matched controls were compared using (a) 10 x 10 pixel boxes (the instrument default sample size), taken from the nasal and temporal peripapillary retina, (b) the average from two of these boxes, and (c) every qualifying pixel within the peripapillary retina. Results - Patients and controls did not differ in blood flow measured using the default sample from a single 10 x 10 pixel box, placed in either the temporal or nasal peripapillary retina, or expressed as the average from these two boxes. However, in histograms using every pixel from the peripapillary retina, NTG patients displayed significantly higher percentages of minimal flow pixels (defined as less than one arbitrary unit of flow: 30% v 19%, p < 0.01), and significantly lower flow in the 25th, 50th, and 75th percentile flow pixel (each p < 0.05) than did age matched controls. Conclusion - NTG is characterised by reduced blood flow in the peripapillary retina, a result suggesting that blood flow deficits accompany, and perhaps may contribute to, disease development in these patients.

Original languageEnglish
Pages (from-to)466-469
Number of pages4
JournalBritish Journal of Ophthalmology
Volume83
Issue number4
StatePublished - 1999

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Low Tension Glaucoma
Retina
Nose
Laser-Doppler Flowmetry
Rheology
Sample Size

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Chung, H. S., Harris, A., Kagemann, L., & Martin, B. (1999). Peripapillary retinal blood flow in normal tension glaucoma. British Journal of Ophthalmology, 83(4), 466-469.

Peripapillary retinal blood flow in normal tension glaucoma. / Chung, Hak Sung; Harris, Alon; Kagemann, Larry; Martin, Bruce.

In: British Journal of Ophthalmology, Vol. 83, No. 4, 1999, p. 466-469.

Research output: Contribution to journalArticle

Chung, HS, Harris, A, Kagemann, L & Martin, B 1999, 'Peripapillary retinal blood flow in normal tension glaucoma', British Journal of Ophthalmology, vol. 83, no. 4, pp. 466-469.
Chung, Hak Sung ; Harris, Alon ; Kagemann, Larry ; Martin, Bruce. / Peripapillary retinal blood flow in normal tension glaucoma. In: British Journal of Ophthalmology. 1999 ; Vol. 83, No. 4. pp. 466-469.
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