Peripheral blood stem cell mobilization - A role for CXC chemokines

Louis M. Pelus, Daniel Horowitz, Scott C. Cooper, Andrew G. King

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

Chemokines induce rapid hematopoietic stem and progenitor cell mobilization and synergize with hematopoietic cytokines in mobilizing stem and progenitor cells. These proteins alone and in combination offer new paradigms for autologous and allogeneic peripheral blood stem cell transplantation (PBSCT). The mechanisms responsible for hematopoietic stem cell (HSC) mobilization either with growth factors or chemokines are largely unknown, but a better understanding of these mechanisms will permit the development of novel, more rapid and efficacious regimens. Studies presented herein indicate that the CXCR2 chemokine receptor that interacts with selective chemokine ligands, particularly GROβ/CXCL2 and GROβ-T, may be the dominant receptor mediating hematopoietic cell mobilization, and that polymorphonuclear neutrophils may be the primary CXCR2 expressing target cell for stem and progenitor cell mobilization.

Original languageEnglish (US)
Pages (from-to)257-275
Number of pages19
JournalCritical Reviews in Oncology/Hematology
Volume43
Issue number3
DOIs
StatePublished - Sep 2002

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Keywords

  • Chemokines
  • GROβ
  • Hematopoietic stem cell mobilization
  • Transplantation

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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