Methamphetamine (METH) is a psychostimulant that is widely known to act directly upon the central nervous system (CNS) and to produce damage to the dopaminergic and serotonergic systems and the blood-brain barrier. Additionally, METH acutely increases oxidative stress, glutamate neurotransmission, and neuroinflammation, all of which are known to mediate METH-induced damage in the brain. In addition to the CNS effects, METH can result in detrimental effects in the periphery, but these effects have not been well characterized. However, relatively recent human case studies illustrate that METH affects the lungs, liver, muscle, kidneys, vasculature, and intestinal tract, resulting in organ dysfunction and the release of cytotoxic molecules into the circulation, including inflammatory mediators. This chapter focuses on the peripheral targets of METH and how damage to these organs might contribute to METH-induced neurotoxicity.
|Original language||English (US)|
|Title of host publication||Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects|
|Number of pages||11|
|State||Published - Apr 15 2016|
- Blood-brain barrier
ASJC Scopus subject areas