Peripheral Neuropathies

Steven S. Scherer, Kleopas A. Kleopa, Merrill D. Benson

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Peripheral neuropathies are among the most common inherited neurologic diseases. Neuropathy may be a key -aspect of an inherited disease, or may be overshadowed by the other manifestations of a syndrome. Inherited demyelinating neuropathies are usually caused by mutations in genes expressed by myelinating Schwann cells. Inherited axonal neuropathies are mainly caused by mutations in genes expressed by neurons, with some important exceptions, such as the genes that cause familial amyloidotic neuropathies. More than 70 different causes of nonsyndromic and 120 causes of syndromic inherited neuropathy have been described.

Original languageEnglish (US)
Title of host publicationRosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
Pages1051-1074
Number of pages24
ISBN (Electronic)9780124105294
ISBN (Print)9780124105492
DOIs
StatePublished - Nov 13 2014

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Keywords

  • Amyloid
  • Axon
  • CMT
  • Charcot-Marie-Tooth
  • GJB1 MFN2
  • MPZ
  • Myelin
  • Neuropathy
  • PMP22

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Scherer, S. S., Kleopa, K. A., & Benson, M. D. (2014). Peripheral Neuropathies. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition (pp. 1051-1074). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-410529-4.00088-7