Peripheral precocious puberty: Causes and current management

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Abstract

Background: Peripheral precocious puberty (PPP) results from sex steroid exposure by a process other than activation of the hypothalamic-pituitary- gonadal axis. It is much less common than central precocious puberty and may be congenital or acquired. Causes of PPP range from well-characterized genetic mutations to those conditions without a known etiology (idiopathic). Medical evaluation and treatment of affected children is guided by the presenting features and ultimate diagnosis. Conclusions: Carefully executed and collaborative multicenter investigations are essential to expand our knowledge of the underlying pathophysiology, optimal therapy and ultimate outcomes in children with PPP.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalHormone Research
Volume71
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 2009

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Keywords

  • Familial male-limited precocious puberty
  • McCune-Albright syndrome
  • Precocious puberty

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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