Peripheral precocious puberty including congenital adrenal hyperplasia: causes, consequences, management and outcomes

Nadine G. Haddad, Erica A. Eugster

Research output: Contribution to journalReview article


Peripheral precocious puberty results from peripheral production of sex steroids independent of activation of the hypothalamic-pituitary gonadal axis. It is much less common than central precocious puberty. Causes are variable and can be congenital or acquired. In this review, we will discuss the diagnosis and management of the most common etiologies including congenital adrenal hyperplasia, McCune Albright syndrome, familial male-limited precocious puberty, and adrenal and gonadal tumors.



  • adrenal tumors
  • congenital adrenal hyperplasia
  • familial male-limited precocious puberty
  • gonadal tumors
  • McCune Albright syndrome
  • peripheral precocious puberty

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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