Peripheral T-cell lymphoma in lck(pr)-bcl-2 transgenic mice

G. P. Linette, J. L. Hess, C. L. Sentman, S. J. Korsmeyer

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

t(14;18) is the most common translocation in human lymphoid malignancy and results in bcl-2 overexpression. bcl-2 blocks apoptosis and constitutes the initial member of a new category of oncogenes, ie, regulators of cell death. Bcl-2-Ig transgenic mice develop follicular hyperplasia and progress to malignant B-cell lymphoma. To assess the oncogenic potential of bcl-2 in the T-cell lineage, a cohort of 68 lck(pr)-bcl-2 transgenic mice and 56 control littermates were monitored for signs of malignancy over a 24-month period. Eighteen (26%) lck(pr)-bcl-2 mice developed diffuse, predominantly large- cell lymphomas at a mean age of 18 months. In contrast, only one nontransgenic control mouse developed lymphoma. CD3 surface expression and clonal T-cell receptor β rearrangements support the T-lineage classification of these neoplasms. lck(pr)-bcl-2-enforced lymphomas are predominantly CD4+CD8-, consistent with a mature peripheral T-cell phenotype. These data provide support for the thesis that violation of homeostasis through the repression of cell death can be a primary mechanism of tumorigenesis in multiple lineages.

Original languageEnglish (US)
Pages (from-to)1255-1260
Number of pages6
JournalBlood
Volume86
Issue number4
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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