Peripheral T-cell lymphoma in lck(pr)-bcl-2 transgenic mice

G. P. Linette, J. L. Hess, C. L. Sentman, S. J. Korsmeyer

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Abstract

t(14;18) is the most common translocation in human lymphoid malignancy and results in bcl-2 overexpression. bcl-2 blocks apoptosis and constitutes the initial member of a new category of oncogenes, ie, regulators of cell death. Bcl-2-Ig transgenic mice develop follicular hyperplasia and progress to malignant B-cell lymphoma. To assess the oncogenic potential of bcl-2 in the T-cell lineage, a cohort of 68 lck(pr)-bcl-2 transgenic mice and 56 control littermates were monitored for signs of malignancy over a 24-month period. Eighteen (26%) lck(pr)-bcl-2 mice developed diffuse, predominantly large- cell lymphomas at a mean age of 18 months. In contrast, only one nontransgenic control mouse developed lymphoma. CD3 surface expression and clonal T-cell receptor β rearrangements support the T-lineage classification of these neoplasms. lck(pr)-bcl-2-enforced lymphomas are predominantly CD4+CD8-, consistent with a mature peripheral T-cell phenotype. These data provide support for the thesis that violation of homeostasis through the repression of cell death can be a primary mechanism of tumorigenesis in multiple lineages.

Original languageEnglish (US)
Pages (from-to)1255-1260
Number of pages6
JournalBlood
Volume86
Issue number4
StatePublished - Jan 1 1995

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Peripheral T-Cell Lymphoma
T-cells
Cell death
Transgenic Mice
Lymphoma
Cell Death
T-Cell Antigen Receptor
T-Lymphocytes
Neoplasms
Lymphoma, Large B-Cell, Diffuse
Cells
B-Cell Lymphoma
Cell Lineage
Apoptosis
Oncogenes
Hyperplasia
Carcinogenesis
Homeostasis
Phenotype

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Linette, G. P., Hess, J. L., Sentman, C. L., & Korsmeyer, S. J. (1995). Peripheral T-cell lymphoma in lck(pr)-bcl-2 transgenic mice. Blood, 86(4), 1255-1260.

Peripheral T-cell lymphoma in lck(pr)-bcl-2 transgenic mice. / Linette, G. P.; Hess, J. L.; Sentman, C. L.; Korsmeyer, S. J.

In: Blood, Vol. 86, No. 4, 01.01.1995, p. 1255-1260.

Research output: Contribution to journalArticle

Linette, GP, Hess, JL, Sentman, CL & Korsmeyer, SJ 1995, 'Peripheral T-cell lymphoma in lck(pr)-bcl-2 transgenic mice', Blood, vol. 86, no. 4, pp. 1255-1260.
Linette GP, Hess JL, Sentman CL, Korsmeyer SJ. Peripheral T-cell lymphoma in lck(pr)-bcl-2 transgenic mice. Blood. 1995 Jan 1;86(4):1255-1260.
Linette, G. P. ; Hess, J. L. ; Sentman, C. L. ; Korsmeyer, S. J. / Peripheral T-cell lymphoma in lck(pr)-bcl-2 transgenic mice. In: Blood. 1995 ; Vol. 86, No. 4. pp. 1255-1260.
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