Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment

Jaroslaw Harezlak, Steven Buchthal, Michael Taylor, Giovanni Schifitto, Jianhui Zhong, Eric Daar, Jeffrey Alger, Elyse Singer, Thomas Campbell, Constantin Yiannoutsos, Ronald Cohen, Bradford Navia

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

Objective: To determine whether cognitive impairment and brain injury as measured by proton magnetic resonance spectroscopy (MRS) persist in the setting of HAART. Design: This study is an observational cohort study. Methods: MRS was performed in 268 patients: HIV-negative controls (N = 28), HIV-positive neuroasymptomatic individuals (N = 124), and individuals with AIDS dementia complex (ADC; N = 50) on stable antiretroviral therapy (ART) with a mean duration of infection of 12 years and CD4+ cell count of 309 cells/μl. Four metabolites were measured over creatine: N-acetyl aspartate (NAA), marker of neuronal integrity; choline (Cho), myoinositol, markers of inflammation, and glutamate and glutamine (Glx) in the basal ganglia, frontal white matter (FWM), and mid-frontal cortex. Analyses included analysis of variance, analysis of covariance, linear, and nonparametric regression models. Results: Cognitive impairment was found in 48% of HIV-infected individuals. Both HIV-positive groups showed significant increases in myoinositol/creatine or Cho/creatine in all brain regions when compared to controls; a significant decrease in Glx/creatine in the FWM was observed in the neuroasymptomatic group; and only individuals with ADC showed a significant reduction in NAA/creatine, although a significant trend for decreasing NAA/creatine in the basal ganglia was found across the groups. Effects related to aging and duration of infection, but not central nervous system penetration effectiveness were observed. Conclusion: Brain inflammatory changes remain ubiquitous among HIV-infected individuals, whereas neuronal injury occurs predominantly in those with cognitive impairment. Together these findings indicate that despite the widespread use of HAART, HIV-associated cognitive impairment and brain injury persist in the setting of chronic and stable disease.

Original languageEnglish
Pages (from-to)625-633
Number of pages9
JournalAIDS
Volume25
Issue number5
DOIs
StatePublished - Mar 13 2011

Fingerprint

Creatine
HIV
Inflammation
Wounds and Injuries
Highly Active Antiretroviral Therapy
Inositol
Choline
Basal Ganglia
Brain Injuries
Analysis of Variance
Therapeutics
AIDS Dementia Complex
Central Nervous System Infections
Brain
Frontal Lobe
CD4 Lymphocyte Count
Glutamine
Observational Studies
Cognitive Dysfunction
Glutamic Acid

Keywords

  • antiretroviral therapies
  • HIV dementia
  • magnetic resonance spectroscopy
  • neuroimaging

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment. / Harezlak, Jaroslaw; Buchthal, Steven; Taylor, Michael; Schifitto, Giovanni; Zhong, Jianhui; Daar, Eric; Alger, Jeffrey; Singer, Elyse; Campbell, Thomas; Yiannoutsos, Constantin; Cohen, Ronald; Navia, Bradford.

In: AIDS, Vol. 25, No. 5, 13.03.2011, p. 625-633.

Research output: Contribution to journalArticle

Harezlak, J, Buchthal, S, Taylor, M, Schifitto, G, Zhong, J, Daar, E, Alger, J, Singer, E, Campbell, T, Yiannoutsos, C, Cohen, R & Navia, B 2011, 'Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment', AIDS, vol. 25, no. 5, pp. 625-633. https://doi.org/10.1097/QAD.0b013e3283427da7
Harezlak, Jaroslaw ; Buchthal, Steven ; Taylor, Michael ; Schifitto, Giovanni ; Zhong, Jianhui ; Daar, Eric ; Alger, Jeffrey ; Singer, Elyse ; Campbell, Thomas ; Yiannoutsos, Constantin ; Cohen, Ronald ; Navia, Bradford. / Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment. In: AIDS. 2011 ; Vol. 25, No. 5. pp. 625-633.
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