Persistent shedding of mouse hepatitis virus in mouse lines selected for genetic differences in alcohol sensitivity

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Two replicate lines of mice, selected for hyperactivity and hypoactivity after ethanol administration, had been enzootically infected with mouse hepatitis virus (MHV) for over a decade. A cessation of breeding program (also known as a "burnout") was implemented to eradicate the virus and was successful in only one of the four lines. Subsequent investigation demonstrated persistent shedding of MHV in two lines of mice for at least 7 weeks. To the author's knowledge, this is the first documented case of clinically inapparent persistent shedding of MHV in mice that are not genetically engineered.

Original languageEnglish (US)
Pages (from-to)19-21
Number of pages3
JournalContemporary Topics in Laboratory Animal Science
Volume43
Issue number5
StatePublished - Sep 2004
Externally publishedYes

Fingerprint

Murine hepatitis virus
genetic lines
alcohols
Alcohols
mice
Breeding
Ethanol
ethanol
Viruses
viruses
breeding

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

@article{cfc44785ea4e480e8303a85545372d59,
title = "Persistent shedding of mouse hepatitis virus in mouse lines selected for genetic differences in alcohol sensitivity",
abstract = "Two replicate lines of mice, selected for hyperactivity and hypoactivity after ethanol administration, had been enzootically infected with mouse hepatitis virus (MHV) for over a decade. A cessation of breeding program (also known as a {"}burnout{"}) was implemented to eradicate the virus and was successful in only one of the four lines. Subsequent investigation demonstrated persistent shedding of MHV in two lines of mice for at least 7 weeks. To the author's knowledge, this is the first documented case of clinically inapparent persistent shedding of MHV in mice that are not genetically engineered.",
author = "Debra Hickman",
year = "2004",
month = "9",
language = "English (US)",
volume = "43",
pages = "19--21",
journal = "Journal of the American Association for Laboratory Animal Science",
issn = "1559-6109",
publisher = "American Association for Laboratory Animal Science",
number = "5",

}

TY - JOUR

T1 - Persistent shedding of mouse hepatitis virus in mouse lines selected for genetic differences in alcohol sensitivity

AU - Hickman, Debra

PY - 2004/9

Y1 - 2004/9

N2 - Two replicate lines of mice, selected for hyperactivity and hypoactivity after ethanol administration, had been enzootically infected with mouse hepatitis virus (MHV) for over a decade. A cessation of breeding program (also known as a "burnout") was implemented to eradicate the virus and was successful in only one of the four lines. Subsequent investigation demonstrated persistent shedding of MHV in two lines of mice for at least 7 weeks. To the author's knowledge, this is the first documented case of clinically inapparent persistent shedding of MHV in mice that are not genetically engineered.

AB - Two replicate lines of mice, selected for hyperactivity and hypoactivity after ethanol administration, had been enzootically infected with mouse hepatitis virus (MHV) for over a decade. A cessation of breeding program (also known as a "burnout") was implemented to eradicate the virus and was successful in only one of the four lines. Subsequent investigation demonstrated persistent shedding of MHV in two lines of mice for at least 7 weeks. To the author's knowledge, this is the first documented case of clinically inapparent persistent shedding of MHV in mice that are not genetically engineered.

UR - http://www.scopus.com/inward/record.url?scp=4544272988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4544272988&partnerID=8YFLogxK

M3 - Article

C2 - 15461435

AN - SCOPUS:4544272988

VL - 43

SP - 19

EP - 21

JO - Journal of the American Association for Laboratory Animal Science

JF - Journal of the American Association for Laboratory Animal Science

SN - 1559-6109

IS - 5

ER -