Personal history of prostate cancer and increased risk of incident melanoma in the United States

Wen Qing Li, Abrar A. Qureshi, Jing Ma, Alisa M. Goldstein, Edward L. Giovannucci, Meir J. Stampfer, Jiali Han

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Purpose Steroid hormones, particularly androgens, play a major role in prostatic carcinogenesis. Personal history of severe acne, a surrogate for higher androgen activity, has been associated with an increased risk of prostate cancer (PCa), and one recent study indicated that severe teenage acne was a novel risk factor for melanoma. These findings suggest a possible relationship between PCa and risk of melanoma. We prospectively evaluated this association among US men. Methods A total of 42,372 participants in the Health Professionals' Follow-Up Study (HPFS; 1986 to 2010) were included. Biennially self-reported PCa diagnosis was confirmed using pathology reports. Diagnosis of melanoma and nonmelanoma skin cancer (NMSC) was self-reported biennially, and diagnosis of melanoma was pathologically confirmed. We sought to confirm the association in 18,603 participants from the Physicians' Health Study (PHS; 1982 to 1998). Results We identified 539 melanomas in the HPFS. Personal history of PCa was associated with an increased risk of melanoma (multivariate-adjusted hazard ratio [HR], 1.83; 95% CI, 1.32 to 2.54). Although we also detected a marginally increased risk of NMSC associated with PCa (HR, 1.08; 95% CI, 0.995 to 1.16), the difference in the magnitude of the association between melanoma and NMSC was significant (P for heterogeneity < .002). We did not find an altered risk of melanoma associated with personal history of other cancers. The association between PCa and risk of incident melanoma was confirmed in the PHS (HR, 2.17; 95% CI, 1.12 to 4.21). Conclusion Personal history of PCa is associated with an increased risk of melanoma, which may not be entirely a result of greater medical scrutiny.

Original languageEnglish (US)
Pages (from-to)4394-4399
Number of pages6
JournalJournal of Clinical Oncology
Volume31
Issue number35
DOIs
StatePublished - Dec 10 2013

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Melanoma
Prostatic Neoplasms
Skin Neoplasms
Acne Vulgaris
Androgens
Health
Carcinogenesis
Steroids
Hormones
Pathology
Physicians

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Li, W. Q., Qureshi, A. A., Ma, J., Goldstein, A. M., Giovannucci, E. L., Stampfer, M. J., & Han, J. (2013). Personal history of prostate cancer and increased risk of incident melanoma in the United States. Journal of Clinical Oncology, 31(35), 4394-4399. https://doi.org/10.1200/JCO.2013.51.1915

Personal history of prostate cancer and increased risk of incident melanoma in the United States. / Li, Wen Qing; Qureshi, Abrar A.; Ma, Jing; Goldstein, Alisa M.; Giovannucci, Edward L.; Stampfer, Meir J.; Han, Jiali.

In: Journal of Clinical Oncology, Vol. 31, No. 35, 10.12.2013, p. 4394-4399.

Research output: Contribution to journalReview article

Li, WQ, Qureshi, AA, Ma, J, Goldstein, AM, Giovannucci, EL, Stampfer, MJ & Han, J 2013, 'Personal history of prostate cancer and increased risk of incident melanoma in the United States', Journal of Clinical Oncology, vol. 31, no. 35, pp. 4394-4399. https://doi.org/10.1200/JCO.2013.51.1915
Li, Wen Qing ; Qureshi, Abrar A. ; Ma, Jing ; Goldstein, Alisa M. ; Giovannucci, Edward L. ; Stampfer, Meir J. ; Han, Jiali. / Personal history of prostate cancer and increased risk of incident melanoma in the United States. In: Journal of Clinical Oncology. 2013 ; Vol. 31, No. 35. pp. 4394-4399.
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T1 - Personal history of prostate cancer and increased risk of incident melanoma in the United States

AU - Li, Wen Qing

AU - Qureshi, Abrar A.

AU - Ma, Jing

AU - Goldstein, Alisa M.

AU - Giovannucci, Edward L.

AU - Stampfer, Meir J.

AU - Han, Jiali

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N2 - Purpose Steroid hormones, particularly androgens, play a major role in prostatic carcinogenesis. Personal history of severe acne, a surrogate for higher androgen activity, has been associated with an increased risk of prostate cancer (PCa), and one recent study indicated that severe teenage acne was a novel risk factor for melanoma. These findings suggest a possible relationship between PCa and risk of melanoma. We prospectively evaluated this association among US men. Methods A total of 42,372 participants in the Health Professionals' Follow-Up Study (HPFS; 1986 to 2010) were included. Biennially self-reported PCa diagnosis was confirmed using pathology reports. Diagnosis of melanoma and nonmelanoma skin cancer (NMSC) was self-reported biennially, and diagnosis of melanoma was pathologically confirmed. We sought to confirm the association in 18,603 participants from the Physicians' Health Study (PHS; 1982 to 1998). Results We identified 539 melanomas in the HPFS. Personal history of PCa was associated with an increased risk of melanoma (multivariate-adjusted hazard ratio [HR], 1.83; 95% CI, 1.32 to 2.54). Although we also detected a marginally increased risk of NMSC associated with PCa (HR, 1.08; 95% CI, 0.995 to 1.16), the difference in the magnitude of the association between melanoma and NMSC was significant (P for heterogeneity < .002). We did not find an altered risk of melanoma associated with personal history of other cancers. The association between PCa and risk of incident melanoma was confirmed in the PHS (HR, 2.17; 95% CI, 1.12 to 4.21). Conclusion Personal history of PCa is associated with an increased risk of melanoma, which may not be entirely a result of greater medical scrutiny.

AB - Purpose Steroid hormones, particularly androgens, play a major role in prostatic carcinogenesis. Personal history of severe acne, a surrogate for higher androgen activity, has been associated with an increased risk of prostate cancer (PCa), and one recent study indicated that severe teenage acne was a novel risk factor for melanoma. These findings suggest a possible relationship between PCa and risk of melanoma. We prospectively evaluated this association among US men. Methods A total of 42,372 participants in the Health Professionals' Follow-Up Study (HPFS; 1986 to 2010) were included. Biennially self-reported PCa diagnosis was confirmed using pathology reports. Diagnosis of melanoma and nonmelanoma skin cancer (NMSC) was self-reported biennially, and diagnosis of melanoma was pathologically confirmed. We sought to confirm the association in 18,603 participants from the Physicians' Health Study (PHS; 1982 to 1998). Results We identified 539 melanomas in the HPFS. Personal history of PCa was associated with an increased risk of melanoma (multivariate-adjusted hazard ratio [HR], 1.83; 95% CI, 1.32 to 2.54). Although we also detected a marginally increased risk of NMSC associated with PCa (HR, 1.08; 95% CI, 0.995 to 1.16), the difference in the magnitude of the association between melanoma and NMSC was significant (P for heterogeneity < .002). We did not find an altered risk of melanoma associated with personal history of other cancers. The association between PCa and risk of incident melanoma was confirmed in the PHS (HR, 2.17; 95% CI, 1.12 to 4.21). Conclusion Personal history of PCa is associated with an increased risk of melanoma, which may not be entirely a result of greater medical scrutiny.

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