Personal history of psoriasis and risk of nonmelanoma skin cancer (NMSC) among women in the United States: A population-based cohort study

Hongji Dai, Wen Qing Li, Abrar A. Qureshi, Jiali Han

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background To our knowledge, no prospective studies have examined the association between personal history of psoriasis and risk of nonmelanoma skin cancer. Objective We sought to examine this association based on 2 prospective cohorts, the Nurses' Health Study and Nurses' Health Study II. Methods Diagnoses of nonmelanoma skin cancer, including basal cell carcinoma and squamous cell carcinoma (SCC), were obtained by self-reported questionnaires. Information on clinician-diagnosed psoriasis and diagnosis year was collected and validated with a supplementary questionnaire. Results After 2,487,941 and 2,478,148 person-years of follow-up, we documented 1725 SCC cases and 16,075 basal cell carcinoma cases, respectively. For the combined cohorts, personal history of psoriasis was associated with an elevated risk of SCC, with a multivariate-adjusted relative risk (RR) of 1.51 (95% confidence interval [CI] 1.11-2.05). The associations appeared stronger with increasing psoriasis severity, with RR of 1.42 (95% CI 0.94-2.15) in the mild psoriasis group and RR of 1.99 (95% CI 0.74-5.32) in the moderate to severe psoriasis group (P trend = .03). There was no association between psoriasis and the risk of basal cell carcinoma (RR 0.95; 95% CI 0.75-1.18). Limitations Lack of treatment data may bias the result. Conclusion Personal history of psoriasis may be associated with an increased risk of SCC. Further investigations are warranted to understand the underlying mechanisms.

Original languageEnglish (US)
Pages (from-to)731-735
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume75
Issue number4
DOIs
StatePublished - Oct 1 2016

Fingerprint

Skin Neoplasms
Psoriasis
Cohort Studies
Population
Squamous Cell Carcinoma
Basal Cell Carcinoma
Confidence Intervals
Nurses
Health
Prospective Studies

Keywords

  • basal cell carcinoma
  • cohort study
  • nonmelanoma skin cancer
  • psoriasis
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Dermatology

Cite this

Personal history of psoriasis and risk of nonmelanoma skin cancer (NMSC) among women in the United States : A population-based cohort study. / Dai, Hongji; Li, Wen Qing; Qureshi, Abrar A.; Han, Jiali.

In: Journal of the American Academy of Dermatology, Vol. 75, No. 4, 01.10.2016, p. 731-735.

Research output: Contribution to journalArticle

@article{30408e2e42eb41ea91bfd83081f8bb1c,
title = "Personal history of psoriasis and risk of nonmelanoma skin cancer (NMSC) among women in the United States: A population-based cohort study",
abstract = "Background To our knowledge, no prospective studies have examined the association between personal history of psoriasis and risk of nonmelanoma skin cancer. Objective We sought to examine this association based on 2 prospective cohorts, the Nurses' Health Study and Nurses' Health Study II. Methods Diagnoses of nonmelanoma skin cancer, including basal cell carcinoma and squamous cell carcinoma (SCC), were obtained by self-reported questionnaires. Information on clinician-diagnosed psoriasis and diagnosis year was collected and validated with a supplementary questionnaire. Results After 2,487,941 and 2,478,148 person-years of follow-up, we documented 1725 SCC cases and 16,075 basal cell carcinoma cases, respectively. For the combined cohorts, personal history of psoriasis was associated with an elevated risk of SCC, with a multivariate-adjusted relative risk (RR) of 1.51 (95{\%} confidence interval [CI] 1.11-2.05). The associations appeared stronger with increasing psoriasis severity, with RR of 1.42 (95{\%} CI 0.94-2.15) in the mild psoriasis group and RR of 1.99 (95{\%} CI 0.74-5.32) in the moderate to severe psoriasis group (P trend = .03). There was no association between psoriasis and the risk of basal cell carcinoma (RR 0.95; 95{\%} CI 0.75-1.18). Limitations Lack of treatment data may bias the result. Conclusion Personal history of psoriasis may be associated with an increased risk of SCC. Further investigations are warranted to understand the underlying mechanisms.",
keywords = "basal cell carcinoma, cohort study, nonmelanoma skin cancer, psoriasis, squamous cell carcinoma",
author = "Hongji Dai and Li, {Wen Qing} and Qureshi, {Abrar A.} and Jiali Han",
year = "2016",
month = "10",
day = "1",
doi = "10.1016/j.jaad.2016.05.021",
language = "English (US)",
volume = "75",
pages = "731--735",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Personal history of psoriasis and risk of nonmelanoma skin cancer (NMSC) among women in the United States

T2 - A population-based cohort study

AU - Dai, Hongji

AU - Li, Wen Qing

AU - Qureshi, Abrar A.

AU - Han, Jiali

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background To our knowledge, no prospective studies have examined the association between personal history of psoriasis and risk of nonmelanoma skin cancer. Objective We sought to examine this association based on 2 prospective cohorts, the Nurses' Health Study and Nurses' Health Study II. Methods Diagnoses of nonmelanoma skin cancer, including basal cell carcinoma and squamous cell carcinoma (SCC), were obtained by self-reported questionnaires. Information on clinician-diagnosed psoriasis and diagnosis year was collected and validated with a supplementary questionnaire. Results After 2,487,941 and 2,478,148 person-years of follow-up, we documented 1725 SCC cases and 16,075 basal cell carcinoma cases, respectively. For the combined cohorts, personal history of psoriasis was associated with an elevated risk of SCC, with a multivariate-adjusted relative risk (RR) of 1.51 (95% confidence interval [CI] 1.11-2.05). The associations appeared stronger with increasing psoriasis severity, with RR of 1.42 (95% CI 0.94-2.15) in the mild psoriasis group and RR of 1.99 (95% CI 0.74-5.32) in the moderate to severe psoriasis group (P trend = .03). There was no association between psoriasis and the risk of basal cell carcinoma (RR 0.95; 95% CI 0.75-1.18). Limitations Lack of treatment data may bias the result. Conclusion Personal history of psoriasis may be associated with an increased risk of SCC. Further investigations are warranted to understand the underlying mechanisms.

AB - Background To our knowledge, no prospective studies have examined the association between personal history of psoriasis and risk of nonmelanoma skin cancer. Objective We sought to examine this association based on 2 prospective cohorts, the Nurses' Health Study and Nurses' Health Study II. Methods Diagnoses of nonmelanoma skin cancer, including basal cell carcinoma and squamous cell carcinoma (SCC), were obtained by self-reported questionnaires. Information on clinician-diagnosed psoriasis and diagnosis year was collected and validated with a supplementary questionnaire. Results After 2,487,941 and 2,478,148 person-years of follow-up, we documented 1725 SCC cases and 16,075 basal cell carcinoma cases, respectively. For the combined cohorts, personal history of psoriasis was associated with an elevated risk of SCC, with a multivariate-adjusted relative risk (RR) of 1.51 (95% confidence interval [CI] 1.11-2.05). The associations appeared stronger with increasing psoriasis severity, with RR of 1.42 (95% CI 0.94-2.15) in the mild psoriasis group and RR of 1.99 (95% CI 0.74-5.32) in the moderate to severe psoriasis group (P trend = .03). There was no association between psoriasis and the risk of basal cell carcinoma (RR 0.95; 95% CI 0.75-1.18). Limitations Lack of treatment data may bias the result. Conclusion Personal history of psoriasis may be associated with an increased risk of SCC. Further investigations are warranted to understand the underlying mechanisms.

KW - basal cell carcinoma

KW - cohort study

KW - nonmelanoma skin cancer

KW - psoriasis

KW - squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=84995699971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995699971&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2016.05.021

DO - 10.1016/j.jaad.2016.05.021

M3 - Article

C2 - 27436157

AN - SCOPUS:84995699971

VL - 75

SP - 731

EP - 735

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 4

ER -