Perspective on the osteoclast: An angiogenic cell?

Frank C. Cackowski, G. David Roodman

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

There have been reports recently that the osteoclast stimulates angiogenesis in vitro. We review the evidence suggesting that the osteoclast directly stimulates angiogenesis, and discuss the feasibility of the hypothesis that the osteoclast can be a proangiogenic cell. Reasons supporting the feasibility of this hypothesis include proangiogenic factors produced by osteoclasts, the angiogenic effects of macrophages, the antiangiogenic effects of nitrogen containing bisphosphonates, and the physical proximity of osteoclasts to endothelial cells.

Original languageEnglish (US)
Pages (from-to)12-25
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume1117
DOIs
StatePublished - Nov 2007
Externally publishedYes

Keywords

  • Angiogenesis
  • Bone
  • Osteoclast

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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