Perspective on the osteoclast: An angiogenic cell?

Frank C. Cackowski, G. David Roodman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

There have been reports recently that the osteoclast stimulates angiogenesis in vitro. We review the evidence suggesting that the osteoclast directly stimulates angiogenesis, and discuss the feasibility of the hypothesis that the osteoclast can be a proangiogenic cell. Reasons supporting the feasibility of this hypothesis include proangiogenic factors produced by osteoclasts, the angiogenic effects of macrophages, the antiangiogenic effects of nitrogen containing bisphosphonates, and the physical proximity of osteoclasts to endothelial cells.

Original languageEnglish (US)
Pages (from-to)12-25
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume1117
DOIs
StatePublished - Nov 2007
Externally publishedYes

Fingerprint

Osteoclasts
Macrophages
Endothelial cells
Diphosphonates
Nitrogen
Endothelial Cells
Cells
Proximity
Physical

Keywords

  • Angiogenesis
  • Bone
  • Osteoclast

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Perspective on the osteoclast : An angiogenic cell? / Cackowski, Frank C.; Roodman, G. David.

In: Annals of the New York Academy of Sciences, Vol. 1117, 11.2007, p. 12-25.

Research output: Contribution to journalArticle

@article{b59b76551fd64d348852e833d0f0b70e,
title = "Perspective on the osteoclast: An angiogenic cell?",
abstract = "There have been reports recently that the osteoclast stimulates angiogenesis in vitro. We review the evidence suggesting that the osteoclast directly stimulates angiogenesis, and discuss the feasibility of the hypothesis that the osteoclast can be a proangiogenic cell. Reasons supporting the feasibility of this hypothesis include proangiogenic factors produced by osteoclasts, the angiogenic effects of macrophages, the antiangiogenic effects of nitrogen containing bisphosphonates, and the physical proximity of osteoclasts to endothelial cells.",
keywords = "Angiogenesis, Bone, Osteoclast",
author = "Cackowski, {Frank C.} and Roodman, {G. David}",
year = "2007",
month = "11",
doi = "10.1196/annals.1402.073",
language = "English (US)",
volume = "1117",
pages = "12--25",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Perspective on the osteoclast

T2 - An angiogenic cell?

AU - Cackowski, Frank C.

AU - Roodman, G. David

PY - 2007/11

Y1 - 2007/11

N2 - There have been reports recently that the osteoclast stimulates angiogenesis in vitro. We review the evidence suggesting that the osteoclast directly stimulates angiogenesis, and discuss the feasibility of the hypothesis that the osteoclast can be a proangiogenic cell. Reasons supporting the feasibility of this hypothesis include proangiogenic factors produced by osteoclasts, the angiogenic effects of macrophages, the antiangiogenic effects of nitrogen containing bisphosphonates, and the physical proximity of osteoclasts to endothelial cells.

AB - There have been reports recently that the osteoclast stimulates angiogenesis in vitro. We review the evidence suggesting that the osteoclast directly stimulates angiogenesis, and discuss the feasibility of the hypothesis that the osteoclast can be a proangiogenic cell. Reasons supporting the feasibility of this hypothesis include proangiogenic factors produced by osteoclasts, the angiogenic effects of macrophages, the antiangiogenic effects of nitrogen containing bisphosphonates, and the physical proximity of osteoclasts to endothelial cells.

KW - Angiogenesis

KW - Bone

KW - Osteoclast

UR - http://www.scopus.com/inward/record.url?scp=36549007498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36549007498&partnerID=8YFLogxK

U2 - 10.1196/annals.1402.073

DO - 10.1196/annals.1402.073

M3 - Article

C2 - 18056034

AN - SCOPUS:36549007498

VL - 1117

SP - 12

EP - 25

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -