Pesticides, Microglial NOX2, and Parkinson's Disease

Thomas Taetzsch, Michelle L. Block

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Accumulating evidence indicates that pesticide exposure is associated with an increased risk for developing Parkinson's disease (PD). Several pesticides known to damage dopaminergic (DA) neurons, such as paraquat, rotenone, lindane, and dieldrin also demonstrate the ability to activate microglia, the resident innate immune cell in the brain. While each of these environmental toxicants may impact microglia through unique mechanisms, they all appear to converge on a common final pathway of microglial activation: NADPH oxidase 2 (NOX2) activation. This review will detail the role of microglia in selective DA neurotoxicity, highlight what is currently known about the mechanism of microglial NOX2 activation in these key pesticides, and describe the importance for DA neuron survival and PD etiology.

Original languageEnglish (US)
Pages (from-to)137-149
Number of pages13
JournalJournal of Biochemical and Molecular Toxicology
Volume27
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • Dieldrin
  • Dopaminergic Neurotoxicity
  • Microglia
  • NOX2
  • Oxidative Stress
  • Paraquat
  • Parkinson's Disease
  • Rotenone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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