PET imaging and optical imaging with D-luciferin [11C]methyl ester and D-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice

Ji Quan Wang, Karen E. Pollok, Shanbao Cai, Keith M. Stantz, Gary D. Hutchins, Qi Huang Zheng

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

New carbon-11 labeled d-luciferin analogs d-luciferin [11C] methyl ester ([11C]LMEster, [11C]1) and d-luciferin [ 11C]methyl ether ([11C]LMEther, [11C]2) were synthesized in 25-55% radiochemical yield. PET studies with [ 11C]LMEster and [11C]LMEther demonstrate a lower retention of the C-11 label at 45 min post-injection in luciferase expression tumor. Optical imaging with unlabeled substrate d-luciferin and radiotracers [ 11C]LMEster and [11C]LMEther gave tumor luciferase images within a few minutes of photon counting.

Original languageEnglish (US)
Pages (from-to)331-337
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number2
DOIs
StatePublished - Jan 15 2006

Keywords

  • D-Luciferin [C]methyl ester ([C]LMEster, [ C]1)
  • d-Luciferin [C]methyl ether ([ C]LMEther, [C]2)
  • Gene expression
  • Luciferase
  • Positron emission tomography (PET) imaging

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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