pH-Cycling models to evaluate the effect of low fluoride dentifrice on enamel De- and remineralization

Celso Silva Queiroz, Anderson Takeo Hara, Adriana Franco Paes Leme, Jaime Aparecido Cury

Research output: Contribution to journalArticle

110 Scopus citations


Since the currently available pH-cycling models do not differentiate the anti-caries potential of dentifrices with low fluoride (F) concentration, two models were developed and tested in the present. Bovine enamel blocks were subjected to the models and treated with F solutions containing from 70 to 280 μg F/mL in order to validate them in terms of dose-response effect. The models were also tested by evaluating the dentifrices Colgate Baby (500 μg F/g, as a low fluoride dentifrice), Tandy (1,100 μg F/g, as an active Fdentifrice) and Crest (1,100 μg F/g, as positive control). Enamel mineral loss or gain was assessed by surface and cross-sectional microhardness, and lesion depth was analyzed by polarized light microscopy. The pH-cycling models showed F dose-response effect either reducing enamel demineralization or enhancing remineralization. The low F dentifrice presented anti-caries potential, but it was not equivalent to the dentifrices containing 1,100 μg F/g. These data suggest that the models developed in this study were able to evaluate the anti-caries potential of low F dentifrice either on resistance to demineralization or on enhancement of remineralization.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalBrazilian dental journal
Issue number1
StatePublished - Jan 1 2008


  • Demineralization
  • Dentifrice
  • Fluoride
  • Remineralization

ASJC Scopus subject areas

  • Dentistry(all)

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