Ph-dependent processes in protein

James B. Matthew, Frank R.N. Gurd, Bertrand E. Garcia-Moreno, Margaret A. Flanagan, Keith L. March, Steven J. Shire

Research output: Contribution to journalArticle

165 Scopus citations

Abstract

Recent improvements in the understanding of electrostatic interactions in proteins serve as a focus for the general topic of pH-dependent processes in proteins. The general importance of pH-dependent processes is first set out in terms of hydrogen ion equilibria, stability, ligand interactions, assembly, dynamics, and events in related molecular systems. The development of various theoretical treatments includes various formalisms in addition to the solvent interface model developed by Shire et al. as an extension of the Tanford-Kirkwood treatment. A number of detailed applications of the model are presented and future potentialities are sketched.

Original languageEnglish (US)
Pages (from-to)91-197
Number of pages107
JournalCritical Reviews in Biochemistry and Molecular Biology
Volume18
Issue number2
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'Ph-dependent processes in protein'. Together they form a unique fingerprint.

  • Cite this

    Matthew, J. B., Gurd, F. R. N., Garcia-Moreno, B. E., Flanagan, M. A., March, K. L., & Shire, S. J. (1985). Ph-dependent processes in protein. Critical Reviews in Biochemistry and Molecular Biology, 18(2), 91-197. https://doi.org/10.3109/10409238509085133