pH-dependent processes in proteins.

J. B. Matthew, F. R. Gurd, B. Garcia-Moreno, M. A. Flanagan, K. L. March, S. J. Shire

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

Recent improvements in the understanding of electrostatic interactions in proteins serve as a focus for the general topic of pH-dependent processes in proteins. The general importance of pH-dependent processes is first set out in terms of hydrogen ion equilibria, stability, ligand interactions, assembly, dynamics, and events in related molecular systems. The development of various theoretical treatments includes various formalisms in addition to the solvent interface model developed by Shire et al. as an extension of the Tanford-Kirkwood treatment. A number of detailed applications of the model are presented and future potentialities are sketched.

Original languageEnglish
Pages (from-to)91-197
Number of pages107
JournalCRC critical reviews in biochemistry
Volume18
Issue number2
StatePublished - 1985

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Coulomb interactions
Static Electricity
Protons
Proteins
Ligands

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Biochemistry

Cite this

Matthew, J. B., Gurd, F. R., Garcia-Moreno, B., Flanagan, M. A., March, K. L., & Shire, S. J. (1985). pH-dependent processes in proteins. CRC critical reviews in biochemistry, 18(2), 91-197.

pH-dependent processes in proteins. / Matthew, J. B.; Gurd, F. R.; Garcia-Moreno, B.; Flanagan, M. A.; March, K. L.; Shire, S. J.

In: CRC critical reviews in biochemistry, Vol. 18, No. 2, 1985, p. 91-197.

Research output: Contribution to journalArticle

Matthew, JB, Gurd, FR, Garcia-Moreno, B, Flanagan, MA, March, KL & Shire, SJ 1985, 'pH-dependent processes in proteins.', CRC critical reviews in biochemistry, vol. 18, no. 2, pp. 91-197.
Matthew JB, Gurd FR, Garcia-Moreno B, Flanagan MA, March KL, Shire SJ. pH-dependent processes in proteins. CRC critical reviews in biochemistry. 1985;18(2):91-197.
Matthew, J. B. ; Gurd, F. R. ; Garcia-Moreno, B. ; Flanagan, M. A. ; March, K. L. ; Shire, S. J. / pH-dependent processes in proteins. In: CRC critical reviews in biochemistry. 1985 ; Vol. 18, No. 2. pp. 91-197.
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