Phacoemulsification, intraocular lens implantation, and trabeculectomy, with or without mitomycin C

V. D. Bhavnani, Louis Cantor, J. C. Hoop, A. A. Dobler, S. P. Sanders, T. W. Samuelson, W. E. Sponsel

Research output: Contribution to journalArticle

Abstract

Purpose. To evaluate the potential benefit of adjunctive mitomycin C in patients with primary open angle glaucoma, primary angle closure glaucoma, pigmentary or pseudoexfoliative glaucoma, undergoing primary trabeculectomy combined with phacoemulsification and intraocular lens implantation. Methods. 30 eyes of 30 patients were randomized in this prospective, multi-center, double-masked clinical study to receive either mitomycin C (0.4 mg./ml.) or placebo during the combined triple procedure. The difference and relative difference of intraocular pressure (IOP) and visual acuity (VA) were measured preoperatively and at 1,3,6, and 12 months. To check for any biases in the randomization process or clinic, a two-sample t-test was used to test for drug or clinic differences in the mean preoperation measures. An analysis of variance (ANOVA) model was used to calculate the difference and relative difference in the measures using drug and clinic as factors. A p-value < 0.05 was deemed statistically significant for all tests. Results. Results of the two-sample t-test on age, IOP and VA showed no significant difference between the drug groups or the clinic sites. Results of the ANOVA showed that there was no drug effect at any of the visits in any of the measures, including IOP. Conclusions. The use of mitomycin C did not produce any significant reductions in the IOP as compared to the placebo in this study.

Original languageEnglish
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
StatePublished - Feb 15 1996

Fingerprint

Trabeculectomy
Intraocular Lens Implantation
Phacoemulsification
Mitomycin
Intraocular Pressure
Pharmaceutical Preparations
Visual Acuity
Analysis of Variance
Placebos
Angle Closure Glaucoma
Random Allocation
Double-Blind Method
Glaucoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Bhavnani, V. D., Cantor, L., Hoop, J. C., Dobler, A. A., Sanders, S. P., Samuelson, T. W., & Sponsel, W. E. (1996). Phacoemulsification, intraocular lens implantation, and trabeculectomy, with or without mitomycin C. Investigative Ophthalmology and Visual Science, 37(3).

Phacoemulsification, intraocular lens implantation, and trabeculectomy, with or without mitomycin C. / Bhavnani, V. D.; Cantor, Louis; Hoop, J. C.; Dobler, A. A.; Sanders, S. P.; Samuelson, T. W.; Sponsel, W. E.

In: Investigative Ophthalmology and Visual Science, Vol. 37, No. 3, 15.02.1996.

Research output: Contribution to journalArticle

Bhavnani, VD, Cantor, L, Hoop, JC, Dobler, AA, Sanders, SP, Samuelson, TW & Sponsel, WE 1996, 'Phacoemulsification, intraocular lens implantation, and trabeculectomy, with or without mitomycin C', Investigative Ophthalmology and Visual Science, vol. 37, no. 3.
Bhavnani, V. D. ; Cantor, Louis ; Hoop, J. C. ; Dobler, A. A. ; Sanders, S. P. ; Samuelson, T. W. ; Sponsel, W. E. / Phacoemulsification, intraocular lens implantation, and trabeculectomy, with or without mitomycin C. In: Investigative Ophthalmology and Visual Science. 1996 ; Vol. 37, No. 3.
@article{8d72f7a5e4374a0390ef281978556784,
title = "Phacoemulsification, intraocular lens implantation, and trabeculectomy, with or without mitomycin C",
abstract = "Purpose. To evaluate the potential benefit of adjunctive mitomycin C in patients with primary open angle glaucoma, primary angle closure glaucoma, pigmentary or pseudoexfoliative glaucoma, undergoing primary trabeculectomy combined with phacoemulsification and intraocular lens implantation. Methods. 30 eyes of 30 patients were randomized in this prospective, multi-center, double-masked clinical study to receive either mitomycin C (0.4 mg./ml.) or placebo during the combined triple procedure. The difference and relative difference of intraocular pressure (IOP) and visual acuity (VA) were measured preoperatively and at 1,3,6, and 12 months. To check for any biases in the randomization process or clinic, a two-sample t-test was used to test for drug or clinic differences in the mean preoperation measures. An analysis of variance (ANOVA) model was used to calculate the difference and relative difference in the measures using drug and clinic as factors. A p-value < 0.05 was deemed statistically significant for all tests. Results. Results of the two-sample t-test on age, IOP and VA showed no significant difference between the drug groups or the clinic sites. Results of the ANOVA showed that there was no drug effect at any of the visits in any of the measures, including IOP. Conclusions. The use of mitomycin C did not produce any significant reductions in the IOP as compared to the placebo in this study.",
author = "Bhavnani, {V. D.} and Louis Cantor and Hoop, {J. C.} and Dobler, {A. A.} and Sanders, {S. P.} and Samuelson, {T. W.} and Sponsel, {W. E.}",
year = "1996",
month = "2",
day = "15",
language = "English",
volume = "37",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "3",

}

TY - JOUR

T1 - Phacoemulsification, intraocular lens implantation, and trabeculectomy, with or without mitomycin C

AU - Bhavnani, V. D.

AU - Cantor, Louis

AU - Hoop, J. C.

AU - Dobler, A. A.

AU - Sanders, S. P.

AU - Samuelson, T. W.

AU - Sponsel, W. E.

PY - 1996/2/15

Y1 - 1996/2/15

N2 - Purpose. To evaluate the potential benefit of adjunctive mitomycin C in patients with primary open angle glaucoma, primary angle closure glaucoma, pigmentary or pseudoexfoliative glaucoma, undergoing primary trabeculectomy combined with phacoemulsification and intraocular lens implantation. Methods. 30 eyes of 30 patients were randomized in this prospective, multi-center, double-masked clinical study to receive either mitomycin C (0.4 mg./ml.) or placebo during the combined triple procedure. The difference and relative difference of intraocular pressure (IOP) and visual acuity (VA) were measured preoperatively and at 1,3,6, and 12 months. To check for any biases in the randomization process or clinic, a two-sample t-test was used to test for drug or clinic differences in the mean preoperation measures. An analysis of variance (ANOVA) model was used to calculate the difference and relative difference in the measures using drug and clinic as factors. A p-value < 0.05 was deemed statistically significant for all tests. Results. Results of the two-sample t-test on age, IOP and VA showed no significant difference between the drug groups or the clinic sites. Results of the ANOVA showed that there was no drug effect at any of the visits in any of the measures, including IOP. Conclusions. The use of mitomycin C did not produce any significant reductions in the IOP as compared to the placebo in this study.

AB - Purpose. To evaluate the potential benefit of adjunctive mitomycin C in patients with primary open angle glaucoma, primary angle closure glaucoma, pigmentary or pseudoexfoliative glaucoma, undergoing primary trabeculectomy combined with phacoemulsification and intraocular lens implantation. Methods. 30 eyes of 30 patients were randomized in this prospective, multi-center, double-masked clinical study to receive either mitomycin C (0.4 mg./ml.) or placebo during the combined triple procedure. The difference and relative difference of intraocular pressure (IOP) and visual acuity (VA) were measured preoperatively and at 1,3,6, and 12 months. To check for any biases in the randomization process or clinic, a two-sample t-test was used to test for drug or clinic differences in the mean preoperation measures. An analysis of variance (ANOVA) model was used to calculate the difference and relative difference in the measures using drug and clinic as factors. A p-value < 0.05 was deemed statistically significant for all tests. Results. Results of the two-sample t-test on age, IOP and VA showed no significant difference between the drug groups or the clinic sites. Results of the ANOVA showed that there was no drug effect at any of the visits in any of the measures, including IOP. Conclusions. The use of mitomycin C did not produce any significant reductions in the IOP as compared to the placebo in this study.

UR - http://www.scopus.com/inward/record.url?scp=33750166194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750166194&partnerID=8YFLogxK

M3 - Article

VL - 37

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 3

ER -