Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing.

Ashley P. Barlow, Xiaojie Zhou, John E. Barnes, Steve H. Hoke, Thomas H. Eichhold, Roger D. Gibb, Nivedita B. Ramji, Tao He, Sheri A. Hunt, Michael Kowolik, Marta Somogyi-Mann

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The IntelliClean System from Sonicare and Crest combines a rechargeable sonic power toothbrush and a novel liquid toothpaste into one integrated system, providing the opportunity to re-dose with toothpaste during the brushing cycle. The purpose of this study was to investigate cleaning effects from in-mouth re-dosing with toothpaste during the brushing cycle vs conventional bolus dosing. This was a randomized, examiner-blind, six-period, crossover clinical study. Eighteen adult subjects used an experimental integrated system employing either a re-dosing regimen (2 doses at the start of brushing with 1 additional in-mouth dose during the last 30 seconds of brushing [2+1]) or a conventional regimen (2 doses at the start of brushing only [2+0]). Gingival crevicular fluid (GCF) was sampled at the final brushing quadrant from a preselected site in the gingival sulcus using filter strips at baseline and at 4, 15, and 120 minutes postbrushing. Mean change from baseline in the concentrations of total facultative anaerobes (TFAs) and gram-negative anaerobes (GNAs) in the GCF at 120 minutes posttreatment were modeled separately using general linear mixed models. Area under the curve of surfactant (sodium dodecyl sulfate [SDS]) in GCF over 2 hours postbrushing was calculated and modeled using an analysis of variance model. All hypotheses were tested 2-sided at the 5% significance level. Relative to the conventional regimen, the re-dosing (2+1) regimen produced a significantly greater reduction in log10 (TFA colony-forming units [CFU]/microL GCF) after brushing, 0.99+/-0.12 vs 0.65+/-0.12 (mean change +/- standard error), and a significantly greater reduction in log10 (GNA CFU/microL GCF) after brushing, 0.75 +/-0.14 vs 0.45 +/- 0.14. The re-dosing regimen led to significantly more SDS in GCF relative to the conventional regimen over the 2-hour time period. Re-dosing of liquid toothpaste during the brushing cycle with the IntelliClean System leads to a significantly increased cleaning effect, as defined by a reduced bacterial count in GCF, and significantly higher levels of surfactant in the GCF up to 2 hours after the brushing event.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalCompendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
Volume25
Issue number10 Suppl 1
StatePublished - 2004
Externally publishedYes

Fingerprint

Gingival Crevicular Fluid
Pharmacokinetics
Toothpastes
Surface-Active Agents
Sodium Dodecyl Sulfate
Mouth
Stem Cells
Bacterial Load
Cross-Over Studies
Area Under Curve
Linear Models
Analysis of Variance

Cite this

Barlow, A. P., Zhou, X., Barnes, J. E., Hoke, S. H., Eichhold, T. H., Gibb, R. D., ... Somogyi-Mann, M. (2004). Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 25(10 Suppl 1), 21-27.

Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing. / Barlow, Ashley P.; Zhou, Xiaojie; Barnes, John E.; Hoke, Steve H.; Eichhold, Thomas H.; Gibb, Roger D.; Ramji, Nivedita B.; He, Tao; Hunt, Sheri A.; Kowolik, Michael; Somogyi-Mann, Marta.

In: Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), Vol. 25, No. 10 Suppl 1, 2004, p. 21-27.

Research output: Contribution to journalArticle

Barlow, AP, Zhou, X, Barnes, JE, Hoke, SH, Eichhold, TH, Gibb, RD, Ramji, NB, He, T, Hunt, SA, Kowolik, M & Somogyi-Mann, M 2004, 'Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing.', Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), vol. 25, no. 10 Suppl 1, pp. 21-27.
Barlow, Ashley P. ; Zhou, Xiaojie ; Barnes, John E. ; Hoke, Steve H. ; Eichhold, Thomas H. ; Gibb, Roger D. ; Ramji, Nivedita B. ; He, Tao ; Hunt, Sheri A. ; Kowolik, Michael ; Somogyi-Mann, Marta. / Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing. In: Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995). 2004 ; Vol. 25, No. 10 Suppl 1. pp. 21-27.
@article{dd94cd03f87c4f86ab9ed078a8c5e455,
title = "Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing.",
abstract = "The IntelliClean System from Sonicare and Crest combines a rechargeable sonic power toothbrush and a novel liquid toothpaste into one integrated system, providing the opportunity to re-dose with toothpaste during the brushing cycle. The purpose of this study was to investigate cleaning effects from in-mouth re-dosing with toothpaste during the brushing cycle vs conventional bolus dosing. This was a randomized, examiner-blind, six-period, crossover clinical study. Eighteen adult subjects used an experimental integrated system employing either a re-dosing regimen (2 doses at the start of brushing with 1 additional in-mouth dose during the last 30 seconds of brushing [2+1]) or a conventional regimen (2 doses at the start of brushing only [2+0]). Gingival crevicular fluid (GCF) was sampled at the final brushing quadrant from a preselected site in the gingival sulcus using filter strips at baseline and at 4, 15, and 120 minutes postbrushing. Mean change from baseline in the concentrations of total facultative anaerobes (TFAs) and gram-negative anaerobes (GNAs) in the GCF at 120 minutes posttreatment were modeled separately using general linear mixed models. Area under the curve of surfactant (sodium dodecyl sulfate [SDS]) in GCF over 2 hours postbrushing was calculated and modeled using an analysis of variance model. All hypotheses were tested 2-sided at the 5{\%} significance level. Relative to the conventional regimen, the re-dosing (2+1) regimen produced a significantly greater reduction in log10 (TFA colony-forming units [CFU]/microL GCF) after brushing, 0.99+/-0.12 vs 0.65+/-0.12 (mean change +/- standard error), and a significantly greater reduction in log10 (GNA CFU/microL GCF) after brushing, 0.75 +/-0.14 vs 0.45 +/- 0.14. The re-dosing regimen led to significantly more SDS in GCF relative to the conventional regimen over the 2-hour time period. Re-dosing of liquid toothpaste during the brushing cycle with the IntelliClean System leads to a significantly increased cleaning effect, as defined by a reduced bacterial count in GCF, and significantly higher levels of surfactant in the GCF up to 2 hours after the brushing event.",
author = "Barlow, {Ashley P.} and Xiaojie Zhou and Barnes, {John E.} and Hoke, {Steve H.} and Eichhold, {Thomas H.} and Gibb, {Roger D.} and Ramji, {Nivedita B.} and Tao He and Hunt, {Sheri A.} and Michael Kowolik and Marta Somogyi-Mann",
year = "2004",
language = "English (US)",
volume = "25",
pages = "21--27",
journal = "The Compendium of continuing education in dentistry",
issn = "1548-8578",
publisher = "Dental Learning Systems Co., Inc.",
number = "10 Suppl 1",

}

TY - JOUR

T1 - Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing.

AU - Barlow, Ashley P.

AU - Zhou, Xiaojie

AU - Barnes, John E.

AU - Hoke, Steve H.

AU - Eichhold, Thomas H.

AU - Gibb, Roger D.

AU - Ramji, Nivedita B.

AU - He, Tao

AU - Hunt, Sheri A.

AU - Kowolik, Michael

AU - Somogyi-Mann, Marta

PY - 2004

Y1 - 2004

N2 - The IntelliClean System from Sonicare and Crest combines a rechargeable sonic power toothbrush and a novel liquid toothpaste into one integrated system, providing the opportunity to re-dose with toothpaste during the brushing cycle. The purpose of this study was to investigate cleaning effects from in-mouth re-dosing with toothpaste during the brushing cycle vs conventional bolus dosing. This was a randomized, examiner-blind, six-period, crossover clinical study. Eighteen adult subjects used an experimental integrated system employing either a re-dosing regimen (2 doses at the start of brushing with 1 additional in-mouth dose during the last 30 seconds of brushing [2+1]) or a conventional regimen (2 doses at the start of brushing only [2+0]). Gingival crevicular fluid (GCF) was sampled at the final brushing quadrant from a preselected site in the gingival sulcus using filter strips at baseline and at 4, 15, and 120 minutes postbrushing. Mean change from baseline in the concentrations of total facultative anaerobes (TFAs) and gram-negative anaerobes (GNAs) in the GCF at 120 minutes posttreatment were modeled separately using general linear mixed models. Area under the curve of surfactant (sodium dodecyl sulfate [SDS]) in GCF over 2 hours postbrushing was calculated and modeled using an analysis of variance model. All hypotheses were tested 2-sided at the 5% significance level. Relative to the conventional regimen, the re-dosing (2+1) regimen produced a significantly greater reduction in log10 (TFA colony-forming units [CFU]/microL GCF) after brushing, 0.99+/-0.12 vs 0.65+/-0.12 (mean change +/- standard error), and a significantly greater reduction in log10 (GNA CFU/microL GCF) after brushing, 0.75 +/-0.14 vs 0.45 +/- 0.14. The re-dosing regimen led to significantly more SDS in GCF relative to the conventional regimen over the 2-hour time period. Re-dosing of liquid toothpaste during the brushing cycle with the IntelliClean System leads to a significantly increased cleaning effect, as defined by a reduced bacterial count in GCF, and significantly higher levels of surfactant in the GCF up to 2 hours after the brushing event.

AB - The IntelliClean System from Sonicare and Crest combines a rechargeable sonic power toothbrush and a novel liquid toothpaste into one integrated system, providing the opportunity to re-dose with toothpaste during the brushing cycle. The purpose of this study was to investigate cleaning effects from in-mouth re-dosing with toothpaste during the brushing cycle vs conventional bolus dosing. This was a randomized, examiner-blind, six-period, crossover clinical study. Eighteen adult subjects used an experimental integrated system employing either a re-dosing regimen (2 doses at the start of brushing with 1 additional in-mouth dose during the last 30 seconds of brushing [2+1]) or a conventional regimen (2 doses at the start of brushing only [2+0]). Gingival crevicular fluid (GCF) was sampled at the final brushing quadrant from a preselected site in the gingival sulcus using filter strips at baseline and at 4, 15, and 120 minutes postbrushing. Mean change from baseline in the concentrations of total facultative anaerobes (TFAs) and gram-negative anaerobes (GNAs) in the GCF at 120 minutes posttreatment were modeled separately using general linear mixed models. Area under the curve of surfactant (sodium dodecyl sulfate [SDS]) in GCF over 2 hours postbrushing was calculated and modeled using an analysis of variance model. All hypotheses were tested 2-sided at the 5% significance level. Relative to the conventional regimen, the re-dosing (2+1) regimen produced a significantly greater reduction in log10 (TFA colony-forming units [CFU]/microL GCF) after brushing, 0.99+/-0.12 vs 0.65+/-0.12 (mean change +/- standard error), and a significantly greater reduction in log10 (GNA CFU/microL GCF) after brushing, 0.75 +/-0.14 vs 0.45 +/- 0.14. The re-dosing regimen led to significantly more SDS in GCF relative to the conventional regimen over the 2-hour time period. Re-dosing of liquid toothpaste during the brushing cycle with the IntelliClean System leads to a significantly increased cleaning effect, as defined by a reduced bacterial count in GCF, and significantly higher levels of surfactant in the GCF up to 2 hours after the brushing event.

UR - http://www.scopus.com/inward/record.url?scp=13744258593&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13744258593&partnerID=8YFLogxK

M3 - Article

C2 - 15637977

AN - SCOPUS:13744258593

VL - 25

SP - 21

EP - 27

JO - The Compendium of continuing education in dentistry

JF - The Compendium of continuing education in dentistry

SN - 1548-8578

IS - 10 Suppl 1

ER -