Pharmacogenetics of psychoactive drugs

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Response to psychoactive drugs is subject to genetic variation. Heritable differences in metabolism of antidepressants have been demonstrated and appear to be clinically relevant. More complex genetic variations in drug response are important in alcoholism and possibly other forms of substance abuse. Pharmacologic challenge studies in volunteer twins have shown familial variation in responses to the cholinergic agonist arecoline and to the monoaminergic aginist amphetamine. Arecoline responses also differentiate well-state bipolar patients from controls; this is consistent with a hypothesis of muscarinic supersensitivity in affective disorder. Genetically characterized animal models may be useful in futher analyzing such neurochemical differences.

Original languageEnglish (US)
Pages (from-to)499-505
Number of pages7
JournalJournal of Psychiatric Research
Issue number4
StatePublished - 1987

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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