The only way to determine appropriate medication dosing during pregnancy is to evaluate the pharmacokinetics and pharmacodynamics of individual medications in pregnant women. This type of clinical investigation can present a variety of challenges and concerns. This chapter summarizes what is known about physiologic changes in pregnancy and the impact these changes can have on drug disposition, and provides a model approach for completing pharmacokinetic studies in women during pregnancy.
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)