Pharmacologic treatment for pediatric gastroparesis: A review of the literature

Emma M. Tillman, Keaton S. Smetana, Likeselam Bantu, Merrion G. Buckley

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

There have been a number of agents that have been tried for treatment of gastroparesis over the past 3 decades, with varying levels of success. Guidelines exist for the management of gastroparesis in adults; however, even though the cause of gastroparesis in children is similar to that in adults, no guidelines exist for treating pediatric gastroparesis as studies on the topic are limited. With what little information we have on pediatric gastroparesis, medications used in children’s studies do not seem to demonstrate the same results as in adult patients with gastroparesis; thus, future studies of whether certain medications are effective for treating pediatric gastroparesis and at what dose still need to be conducted. Pharmacological treatment options for pediatric gastroparesis do not show a clear correlation of resolving or even maintaining gastroparesis-associated symptoms or disease state. This article reviews the available studies of drugs that have shown some efficacy, with an emphasis on pediatric studies.

Original languageEnglish (US)
Pages (from-to)120-132
Number of pages13
JournalJournal of Pediatric Pharmacology and Therapeutics
Volume21
Issue number2
DOIs
StatePublished - Mar 1 2018

Keywords

  • Drug therapy
  • Gastroparesis
  • Metoclopramide
  • Pediatrics
  • Prokinetic

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pharmacology (medical)

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