Pharmacological control of gastric acid secretion.

A. M. Zfass, L. McHenry, A. J. Sanyal

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Gastric acid produced by the parietal cells has a significant role in a variety of gastrointestinal diseases, such as duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease. We address acid production by the parietal cell and the pharmacological means to control gastric acid secretion. The physiology of parietal cell acid secretion is reviewed. The role of acid-suppressive therapy with histamine H2 antagonists and omeprazole in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease is discussed. Pharmacology, side-effect profile, and dosage requirements of the histamine H2 antagonists and omeprazole are outlined.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalThe Gastroenterologist
Volume1
Issue number1
StatePublished - Mar 1993

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ASJC Scopus subject areas

  • Gastroenterology

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