Pharmacological Evaluation of an Intra-oral Fluoride-releasing Device in Adolescents

K. Kula, T. Kula, W. Davidson, E. Parker

Research output: Contribution to journalArticle

20 Scopus citations


The purpose of this study was to quantify fluoride (F) concentrations in body fluids of adolescents wearing two intra-oral fluoride-releasing devices (IFRDs) designed to release 0.10 mg Fiday. Fluoride concentrations were determined potentiometrically. No significant increases occurred in urine or serum F concentratiotis during the 26-week device phase. Elevated salivary F concentrations were maintained throughout the device phase when broken or depleted IFRDs were replaced. However, salivary F concentrations returned to pre-device phase values, by 26 weeks when the original IFRDs were maintained. These findings suggest that IFRDs can significantly elevate salivary F concentrations of adolescents without significant elevations in systemic F concentrations.

Original languageEnglish (US)
Pages (from-to)1538-1542
Number of pages5
JournalJournal of dental research
Issue number10
StatePublished - Oct 1987

ASJC Scopus subject areas

  • Dentistry(all)

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