Pharmacological revascularisation in coronary and peripheral vascular disease

Sima T. Tarzami, Jai Pal Singh

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Therapeutic angiogenesis is a novel approach to the treatment of ischaemic or occlusive coronary and peripheral vascular disease. The therapeutic concept is based on the restoration of distal blood flow by the enlargement of existing vessels and tissue perfusion by the induction of new capillaries. Initial studies have focused on the direct application of endothelial growth factors, vascular endothelial growth factor and fibroblast growth factor, or the delivery of genes using either a plasmid or adenoviral vector. Recently, new angiogenic agents such as hypoxia inducible factor-1α, fibroblast growth factor-4, Del-1 and hepatocyte growth factor have entered clinical testing. Moreover, stem-cell therapy or factors mobilising bone marrow progenitor cells have provided evidence for a new avenue for therapeutic angiogenesis. Numerous preclinical studies and several initial clinical trials have provided encouraging data in support of the feasibility of promoting biological revascularisation by the administration of angiogenic factors or cells. 2004

Original languageEnglish (US)
Pages (from-to)1319-1326
Number of pages8
JournalExpert Opinion on Investigational Drugs
Volume13
Issue number10
DOIs
StatePublished - Oct 1 2004

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Keywords

  • Angiogenesis
  • Arteriogenesis
  • Cardiovascular disease
  • Gene therapy
  • Growth factors
  • Ischaemia

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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