Pharmacoproteomics in drug development

Frank Witzmann, Raymond A. Grant

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

The field of proteomics is taking on increased significance as the relevance of investigating and understanding protein expression in disease and drug development is appreciated. Recent advances in proteomics have been driven by the availability of numerous annotated whole-genome sequences and a broad range of technological and bioinformatic developments that underscore the complexity of the proteome. This review briefly addresses some of the various technologies that comprise Expression Proteomics and Functional Proteomics, citing examples where these emerging approaches have been applied to pharmacology, toxicology, and the development of drugs.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalPharmacogenomics Journal
Volume3
Issue number2
DOIs
StatePublished - Jun 17 2003

Keywords

  • Drug development
  • Mass spectrometry
  • Protein array
  • Protein interactions
  • Proteomics
  • Toxicology
  • Two-dimensional electrophoresis

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Genetics

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