Phase I trial of carboplatin and paclitaxel with escalating doses of oral topotecan in patients with solid tumors

Nasser Hanna, Chris Sweeney, Karen Fife, Sheila Dropcho, David E. Seitz

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Carboplatin, paclitaxel, and topotecan have activity against a variety of cancers. This phase I study was designed to determine the maximum tolerated dose of oral topotecan when given in combination with carboplatin and paclitaxel. Eligibility criteria were as follows: Karnofsky Performance score greater than or equal to 80; and adequate hepatic, renal, and bone marrow function. Patients received paclitaxel 175 mg/m2 intravenously followed by carboplatin AUC5 iv on day 1 every 3 weeks for up to 6 cycles. Cohorts of 3 to 5 were treated with escalating doses of oral topotecan on days 1 to 5, initially at 0.75 mg/m2 then 1 mg/m2 and 1.25 mg/m2 in subsequent cohorts. Thirteen patients were treated. Three of three patients in cohort 1 had grade IV neutropenia, with one neutropenic fever and one patient requiring a platelet transfusion. In cohort 2, three of five patients had grade III/IV neutropenia including two with neutropenic fever. Four patients required blood transfusions and one required platelet transfusions. In cohort 3, three of five had grade III/IV neutropenia, one of five had grade IV thrombocytopenia, and one patient required blood transfusions. In conclusion, this three-drug regimen resulted in significant cumulative myelosuppression in the doses and schedule tested in this phase I trial. Subsequent combinations of these drugs should focus on alternate doses or schedules.

Original languageEnglish (US)
Pages (from-to)200-202
Number of pages3
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume26
Issue number2
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

Keywords

  • Carboplatin
  • Oral topotecan
  • Paclitaxel
  • Phase I

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Phase I trial of carboplatin and paclitaxel with escalating doses of oral topotecan in patients with solid tumors'. Together they form a unique fingerprint.

  • Cite this