Phase II trial of high-dose cisplatin plus etoposide plus vinblastine in non-small-cell lung cancer. A hoosier oncology group study

E. Eklund, M. E. Miller, R. Ansari, W. B. Fisher, L. H. Einhorn

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Fifty-one patients with advanced non-small-cell lung cancer were treated on a Hoosier Oncology Group protocol with an aggressive, high-dose cisplatin combination chemotherapy regimen. All patients had a Karnofsky performance status of 80% or higher and had no prior chemotherapy. The drug regimen consisted of cisplatin 30 mg/m2 days one through five, etoposide 40 mg/m2 days one through five, and vinblastine 5 mg/m2 day one. Therapy was given every three weeks for a total of three courses. Forty-five patients were evaluable for response and an objective response was seen in 15 patients (33%) with only one complete responder. The median duration of response was 16.5 weeks. The median survival for the entire group was 29.0 weeks. Toxicity was moderately severe with two treatment-related deaths (4%). Despite an aggressive chemotherapy regimen in a favorable patient population, there was no obvious evidence of a major therapeutic value.

Original languageEnglish (US)
Pages (from-to)412-415
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume14
Issue number5
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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