Phase III results in Genotype 1 naïve patients

Predictors of response with boceprevir and telaprevir combined with pegylated interferon and ribavirin

Paul Y. Kwo

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The addition of telaprevir or boceprevir to pegylated interferon (PEG-INF) and ribavirin (RBV) has improved sustained viral response (SVR) rates in genotype-1-infected individuals. The recent publication of Phase III trials has made it possible to examine pretreatment and on-treatment predictors of response in genotype 1 naïve patients. Both telaprevir- and boceprevir-based therapy improve SVR rates in most treatment groups including individuals who are difficult-to-treat such as those with a high viral load, Black patients and those with advanced fibrosis. Although data sets were not complete, patients with IL28B CT and TT genotype appear to significantly improve when these agents are combined with PEG-INF and RBV. The presence of the IL-28B CC genotype appears to be predictive for a short duration of therapy. On-treatment viral response is also predictive of the SVR: approximately half of the patients are successfully treated with short duration and response-guided therapy.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalLiver International
Volume32
Issue numberSUPPL. 1
DOIs
StatePublished - Feb 2012

Fingerprint

Ribavirin
Interferons
Genotype
Therapeutics
Viral Load
N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide
telaprevir
Fibrosis

Keywords

  • Direct-acting antiviral
  • IL28B
  • Personalized medicine
  • Viral kinetics

ASJC Scopus subject areas

  • Hepatology

Cite this

Phase III results in Genotype 1 naïve patients : Predictors of response with boceprevir and telaprevir combined with pegylated interferon and ribavirin. / Kwo, Paul Y.

In: Liver International, Vol. 32, No. SUPPL. 1, 02.2012, p. 39-43.

Research output: Contribution to journalArticle

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