Phenotypic and genotypic characterization of the Indiana university rat lines selectively bred for high and low alcohol preference

James M. Murphy, Robert B. Stewart, Richard Bell, Nancy E. Badia-Elder, Lucinda G. Carr, William J. McBride, Lawrence Lumeng, Ting Kai Li

Research output: Contribution to journalArticle

267 Citations (Scopus)

Abstract

The Indiana lines of selected rats, the HAD and LAD replicates and the P and NP lines, were bred for high and low alcohol preference. The P and HAD lines have met criteria for an animal model of alcoholism in that they voluntarily consume sufficient ethanol to achieve significant blood alcohol concentrations, and their alcohol-seeking behavior is reinforced by the pharmacological effects of ethanol rather than its taste, caloric content, or other properties. These lines have been characterized extensively for associated behavioral and physiological phenotypes. The P and HAD rats show an enhanced responsiveness to the stimulatory effects of ethanol and reduced sensitivity to the aversive sedative effects of ethanol. Consistent findings with the selected lines include differences in the mesolimbic dopamine reward system, as well as differences in serotonin, GABA, endogenous opioid, and neuropeptide Y systems. Genetic mapping studies have identified quantitative trait loci influencing alcohol preference on chromosomes 3, 4, and 8 in the inbred P/NP rats and on chromosomes 5, 10, 12, and 16 in the noninbred HAD1/LAD1 rats. The elucidation of the genotypes and phenotypes that result in excessive alcohol intake may lead to a better understanding of alcohol abuse and alcoholism and could guide strategies for potential treatment and prevention.

Original languageEnglish
Pages (from-to)363-388
Number of pages26
JournalBehavior Genetics
Volume32
Issue number5
DOIs
StatePublished - Sep 2002

Fingerprint

alcohol
Ethanol
alcohol abuse
alcohols
ethanol
Alcohols
Alcoholism
breeds
rats
chromosomes
Phenotype
line differences
phenotype
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 5
neuropeptide Y
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 3
sedatives

Keywords

  • Alcohol-nonpreferring NP rats
  • Alcohol-preferring P rats
  • High-alcohol-drinking (HAD) rats
  • Low-alcohol-drinking (LAD) rats
  • Phenotypes
  • Selective breeding

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

Phenotypic and genotypic characterization of the Indiana university rat lines selectively bred for high and low alcohol preference. / Murphy, James M.; Stewart, Robert B.; Bell, Richard; Badia-Elder, Nancy E.; Carr, Lucinda G.; McBride, William J.; Lumeng, Lawrence; Li, Ting Kai.

In: Behavior Genetics, Vol. 32, No. 5, 09.2002, p. 363-388.

Research output: Contribution to journalArticle

Murphy, James M. ; Stewart, Robert B. ; Bell, Richard ; Badia-Elder, Nancy E. ; Carr, Lucinda G. ; McBride, William J. ; Lumeng, Lawrence ; Li, Ting Kai. / Phenotypic and genotypic characterization of the Indiana university rat lines selectively bred for high and low alcohol preference. In: Behavior Genetics. 2002 ; Vol. 32, No. 5. pp. 363-388.
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