Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies

Michihiro Kobayashi, Sisi Chen, Rui Gao, Yunpeng Bai, Zhong Yin Zhang, Yan Liu

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The phosphatases of regenerating liver (PRLs), consisting PRL1, PRL2 and PRL3, are dual-specificity protein phosphatases that have been implicated as biomarkers and therapeutic targets in several solid tumors. However, their roles in hematological malignancies are largely unknown. Recent findings demonstrate that PRL2 is important for hematopoietic stem cell self-renewal and proliferation. In addition, both PRL2 and PRL3 are highly expressed in some hematological malignancies, including acute myeloid leukemia (AML), chronic myeloid leukemia (CML), multiple myeloma (MM) and acute lymphoblastic leukemia (ALL). Moreover, PRL deficiency impairs the proliferation and survival of leukemia cells through regulating oncogenic signaling pathways. While PRLs are potential novel therapeutic targets in hematological malignancies, their exact biological function and cellular substrates remain unclear. This review will discuss how PRLs regulate hematopoietic stem cell behavior, what signaling pathways are regulated by PRLs, and how to target PRLs in hematological malignancies. An improved understanding of how PRLs function and how they are regulated may facilitate the development of PRL inhibitors that are effective in cancer treatment.

Original languageEnglish (US)
Pages (from-to)2827-2835
Number of pages9
JournalCell Cycle
Volume13
Issue number18
DOIs
StatePublished - Jan 1 2014

Keywords

  • Hematological malignancy and therapeutic target
  • Hematopoietic stem cell
  • Oncogenic signaling
  • PRL
  • PTP4A
  • Self-renewal

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies'. Together they form a unique fingerprint.

  • Cite this