Phosphate treatment of recurrent calcium stone disease

P. J. Heyburn, W. G. Robertson, M. Peacock

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Abstract

A group of 38 male recurrent idiopathic calcium stone formers were treated with oral supplements of orthophosphate (1 g phosphorus extra in the diet per day) and followed at intervals up to 4 years. The urinary excretion of calcium decreased (p <0.001) and that of inorganic phosphate increased (p <0.001) during treatment. These changes resulted in a small decrease in the supersaturation of urine with respect to calcium oxalate, sufficient to reduce the percentage of urines which exceeded the upper limit of solubility of that salt, and a small increase in the supersaturation of urine with respect to calcium phosphate. The stone episode rate on treatment fell in 35 of the 38 patients from a mean pretreatment value of 0.66 episodes/year to 0.22 episodes/year. The 3 initially most prolific stone formers increased their rate of stone formation during treatment. Plasma biochemistry showed no evidence of parathyroid stimulation.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalNephron
Volume32
Issue number4
StatePublished - Dec 1 1982

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ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

Cite this

Heyburn, P. J., Robertson, W. G., & Peacock, M. (1982). Phosphate treatment of recurrent calcium stone disease. Nephron, 32(4), 314-319.