Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible

report of a case and review of the literature

Victoria L. Woo, Regina Landesberg, Erik Imel, Steven R. Singer, Andrew L. Folpe, Michael Econs, Taeyun Kim, Lara R. Harik, Thomas P. Jacobs

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome that results in renal phosphate wasting with hypophosphatemia. In most cases, the underlying cause of TIO is a small mesenchymal neoplasm that is often difficult to detect, resulting in delayed diagnosis. One such neoplasm is the phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT), an unusual entity with unique morphologic and biochemical features. Most of these tumors are found at appendicular sites with only rare cases reported in the jaws. We describe a PMTMCT involving the mandible in a patient with a protracted history of osteomalacia. A review of the current literature is provided with emphasis on the clinical and histologic features, etiopathogenesis, and management of PMTMCT in the setting of TIO.

Original languageEnglish
Pages (from-to)925-932
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume108
Issue number6
DOIs
StatePublished - Dec 2009

Fingerprint

Mandible
Connective Tissue
Neoplasms
Hypophosphatemia
Paraneoplastic Syndromes
Osteomalacia
Delayed Diagnosis
Jaw
Phosphates
Kidney
Oncogenic osteomalacia

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Dentistry(all)
  • Oral Surgery

Cite this

Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible : report of a case and review of the literature. / Woo, Victoria L.; Landesberg, Regina; Imel, Erik; Singer, Steven R.; Folpe, Andrew L.; Econs, Michael; Kim, Taeyun; Harik, Lara R.; Jacobs, Thomas P.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 108, No. 6, 12.2009, p. 925-932.

Research output: Contribution to journalArticle

Woo, Victoria L. ; Landesberg, Regina ; Imel, Erik ; Singer, Steven R. ; Folpe, Andrew L. ; Econs, Michael ; Kim, Taeyun ; Harik, Lara R. ; Jacobs, Thomas P. / Phosphaturic mesenchymal tumor, mixed connective tissue variant, of the mandible : report of a case and review of the literature. In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 2009 ; Vol. 108, No. 6. pp. 925-932.
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