Phospholipase a2 and its molecular mechanism after spinal cord injury

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Abstract

Phospholipases A2 (PLA2s) are a diverse family of lipolytic enzymes which hydrolyze the acyl bond at the sn-2 position of glycerophospholipids to produce free fatty acids and lysophospholipids. These products are precursors of bioactive eicosanoids and platelet-activating factor which have been implicated in pathological states of numerous acute and chronic neurological disorders. To date, more than 27 isoforms of PLA2 have been found in the mammalian system which can be classified into four major categories: secretory PLA2, cytosolic PLA2, CA 2+-independent PLA2, and platelet-activating factor acetylhydrolases. Multiple isoforms of PLA2 are found in the mammalian spinal cord. Under physiological conditions, PLA2s are involved in diverse cellular responses, including phospholipid digestion and metabolism, host defense, and signal transduction. However, under pathological situations, increased PLA2 activity, excessive production of free fatty acids and their metabolites may lead to the loss of membrane integrity, inflammation, oxidative stress, and subsequent neuronal injury. There is emerging evidence that PLA2 plays a key role in the secondary injury process after traumatic spinal cord injury. This review outlines the current knowledge of the PLA2 in the spinal cord with an emphasis being placed on the possible roles of PLA2 in mediating the secondary SCI.

Original languageEnglish (US)
Pages (from-to)197-205
Number of pages9
JournalMolecular Neurobiology
Volume41
Issue number2-3
DOIs
StatePublished - Jun 2010

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Keywords

  • Apoptosis
  • Inflammation
  • Oxidation
  • Phospholipases A
  • Spinal cord injury

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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