Phospholipid Catabolism

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Metabolism of membrane-associated phospholipids is achieved by a group of enzymes called phospholipases (PLases). PLases hydrolyse phospholipid substrates at varying chemical positions, with the major classes of PLases including A1, A2, C and D. These different classes of enzymes have specificity for site of hydrolysis and typically have more efficient activity on a membrane surface when compared to a monomeric substrate. The majority of these enzymes are soluble and interact with the membrane in a transient fashion brought about by changes in secretion of the enzyme, binding to calcium, appearance of a high affinity lipid substrate, or posttranslational modification. PLases also have different roles in cellular properties and disease states and in some cases are viable drug targets. Overall, this chapter gives an overview of the structure and function of the various types of PLases found in prokaryotic and eukaryotic organisms.

Original languageEnglish (US)
Title of host publicationBiochemistry of Lipids, Lipoproteins and Membranes
Subtitle of host publicationSixth Edition
PublisherElsevier Inc.
Pages237-257
Number of pages21
ISBN (Print)9780444634382
DOIs
StatePublished - Jan 1 2016

Keywords

  • Arachidonic acid
  • Cytosolic phospholipase A
  • Group IIa secretory phospholipase A
  • Lysophospholipid
  • Membrane bilayer
  • Micelle
  • Phospholipase C
  • Phospholipase D
  • Secretory phospholipase A

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Stahelin, R. V. (2016). Phospholipid Catabolism. In Biochemistry of Lipids, Lipoproteins and Membranes: Sixth Edition (pp. 237-257). Elsevier Inc.. https://doi.org/10.1016/B978-0-444-63438-2.00008-0