Phototherapy for neonatal jaundice: In Vivo clearance of bilirubin photoproducts

John F. Ennever, Isabella Knox, Scott C. Denne, William T. Speck

Research output: Contribution to journalArticle

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Abstract

Phototherapy results in the conversion of native bilirubin to more water–soluble configurational and structural isomers. The serum half–life for the configurational isomer, the principal photoproduct in vivo, was determined by high pressure liquid chromatography in six premature infants following cessation of phototherapy. The mean half–life for this isomer was 15 h. The excretion of this isomer, calculated from the measured half–life, is less than half of daily bilirubin production, and therefore cannot account for the total bilirubin elimination observed during phototherapy. The serum concentration of the structural isomer, lumirubin, is lower than that of the configurational isomer; however, excretion is more rapid (serum half–life < 2 h). Because of its rapid excretion, lumirubin may be an important pathway for bilirubin elimination during phototherapy.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalPediatric Research
Volume19
Issue number2
DOIs
StatePublished - Feb 1985

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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