Phototherapy for neonatal jaundice

In Vivo clearance of bilirubin photoproducts

John F. Ennever, Isabella Knox, Scott Denne, William T. Speck

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Phototherapy results in the conversion of native bilirubin to more water–soluble configurational and structural isomers. The serum half–life for the configurational isomer, the principal photoproduct in vivo, was determined by high pressure liquid chromatography in six premature infants following cessation of phototherapy. The mean half–life for this isomer was 15 h. The excretion of this isomer, calculated from the measured half–life, is less than half of daily bilirubin production, and therefore cannot account for the total bilirubin elimination observed during phototherapy. The serum concentration of the structural isomer, lumirubin, is lower than that of the configurational isomer; however, excretion is more rapid (serum half–life <2 h). Because of its rapid excretion, lumirubin may be an important pathway for bilirubin elimination during phototherapy.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalPediatric Research
Volume19
Issue number2
StatePublished - 1985
Externally publishedYes

Fingerprint

Neonatal Jaundice
Phototherapy
Bilirubin
Half-Life
Serum
Premature Infants
High Pressure Liquid Chromatography
lumirubin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Phototherapy for neonatal jaundice : In Vivo clearance of bilirubin photoproducts. / Ennever, John F.; Knox, Isabella; Denne, Scott; Speck, William T.

In: Pediatric Research, Vol. 19, No. 2, 1985, p. 205-208.

Research output: Contribution to journalArticle

Ennever, JF, Knox, I, Denne, S & Speck, WT 1985, 'Phototherapy for neonatal jaundice: In Vivo clearance of bilirubin photoproducts', Pediatric Research, vol. 19, no. 2, pp. 205-208.
Ennever, John F. ; Knox, Isabella ; Denne, Scott ; Speck, William T. / Phototherapy for neonatal jaundice : In Vivo clearance of bilirubin photoproducts. In: Pediatric Research. 1985 ; Vol. 19, No. 2. pp. 205-208.
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