Phyllodes tumours of the breast: A consensus review

Benjamin Y. Tan, Geza Acs, Sophia K. Apple, Sunil Badve, Ira J. Bleiweiss, Edi Brogi, José P. Calvo, David J. Dabbs, Ian O. Ellis, Vincenzo Eusebi, Gelareh Farshid, Stephen B. Fox, Shu Ichihara, Sunil R. Lakhani, Emad A. Rakha, Jorge S. Reis-Filho, Andrea L. Richardson, Aysegul Sahin, Fernando C. Schmitt, Stuart J. SchnittKalliopi P. Siziopikou, Fernando A. Soares, Gary M. Tse, Anne Vincent-Salomon, Puay Hoon Tan

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pathologists. Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic. Phyllodes tumours are treated by surgical excision. However, there is no consensus on the definition of an appropriate surgical margin to ensure completeness of excision and reduction of recurrence risk. Interpretive subjectivity, overlapping histological diagnostic criteria, suboptimal correlation between histological classification and clinical behaviour and the lack of robust molecular predictors of outcome make further investigation of the pathogenesis of these fascinating tumours a matter of active research. This review consolidates the current understanding of their pathobiology and clinical behaviour, and includes proposals for a rational approach to the classification and management of phyllodes tumours.

Original languageEnglish (US)
Pages (from-to)5-21
Number of pages17
JournalHistopathology
Volume68
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Phyllodes Tumor
Consensus
Breast
Fibroadenoma
Neoplasm Grading
Risk Reduction Behavior
Sarcoma
Carcinoma
Recurrence
Research
Neoplasms

Keywords

  • Classification
  • Fibroadenoma
  • Malignant
  • Metastasis
  • Phyllodes

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Tan, B. Y., Acs, G., Apple, S. K., Badve, S., Bleiweiss, I. J., Brogi, E., ... Tan, P. H. (2016). Phyllodes tumours of the breast: A consensus review. Histopathology, 68(1), 5-21. https://doi.org/10.1111/his.12876

Phyllodes tumours of the breast : A consensus review. / Tan, Benjamin Y.; Acs, Geza; Apple, Sophia K.; Badve, Sunil; Bleiweiss, Ira J.; Brogi, Edi; Calvo, José P.; Dabbs, David J.; Ellis, Ian O.; Eusebi, Vincenzo; Farshid, Gelareh; Fox, Stephen B.; Ichihara, Shu; Lakhani, Sunil R.; Rakha, Emad A.; Reis-Filho, Jorge S.; Richardson, Andrea L.; Sahin, Aysegul; Schmitt, Fernando C.; Schnitt, Stuart J.; Siziopikou, Kalliopi P.; Soares, Fernando A.; Tse, Gary M.; Vincent-Salomon, Anne; Tan, Puay Hoon.

In: Histopathology, Vol. 68, No. 1, 01.01.2016, p. 5-21.

Research output: Contribution to journalArticle

Tan, BY, Acs, G, Apple, SK, Badve, S, Bleiweiss, IJ, Brogi, E, Calvo, JP, Dabbs, DJ, Ellis, IO, Eusebi, V, Farshid, G, Fox, SB, Ichihara, S, Lakhani, SR, Rakha, EA, Reis-Filho, JS, Richardson, AL, Sahin, A, Schmitt, FC, Schnitt, SJ, Siziopikou, KP, Soares, FA, Tse, GM, Vincent-Salomon, A & Tan, PH 2016, 'Phyllodes tumours of the breast: A consensus review', Histopathology, vol. 68, no. 1, pp. 5-21. https://doi.org/10.1111/his.12876
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E et al. Phyllodes tumours of the breast: A consensus review. Histopathology. 2016 Jan 1;68(1):5-21. https://doi.org/10.1111/his.12876
Tan, Benjamin Y. ; Acs, Geza ; Apple, Sophia K. ; Badve, Sunil ; Bleiweiss, Ira J. ; Brogi, Edi ; Calvo, José P. ; Dabbs, David J. ; Ellis, Ian O. ; Eusebi, Vincenzo ; Farshid, Gelareh ; Fox, Stephen B. ; Ichihara, Shu ; Lakhani, Sunil R. ; Rakha, Emad A. ; Reis-Filho, Jorge S. ; Richardson, Andrea L. ; Sahin, Aysegul ; Schmitt, Fernando C. ; Schnitt, Stuart J. ; Siziopikou, Kalliopi P. ; Soares, Fernando A. ; Tse, Gary M. ; Vincent-Salomon, Anne ; Tan, Puay Hoon. / Phyllodes tumours of the breast : A consensus review. In: Histopathology. 2016 ; Vol. 68, No. 1. pp. 5-21.
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